|PROSITE documentation PDOC51433 [for PROSITE entry PS51433]|
The highly conserved PNT (or Pointed) domain is found within a subset of the Ets transcription factors (see <PDOC00374>), including mammalian Ets-1, Ets-2, Erg, Fli-1, GABPα, and Tel, as well as Drosophila Pnt-P2 and Yan. The PNT domain is structurally related to the larger group of SAM domains (see <PDOC50105>) through a common tertiary arrangement of four α-helices (see <PDB:1SXE>). A role in protein-protein association has been established for the PNT domain [1,2].
The profiles we developed cover the entire PNT domain.Last update:
January 2009 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Potter M.D., Buijs A., Kreider B., van Rompaey L., Grosveld G.C.|
|Title||Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6.|
|2||Authors||Mackereth C.D., Schaerpf M., Gentile L.N., MacIntosh S.E., Slupsky C.M., McIntosh L.P.|
|Title||Diversity in structure and function of the Ets family PNT domains.|
|Source||J. Mol. Biol. 342:1249-1264(2004).|