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PROSITE documentation PDOC51751 [for PROSITE entry PS51751]

EXPERA domain profile


The EXPERA (EXPanded EBP superfamilly) domain is conserved among the following protein families:

  • Vertebrate TM6SF1 (Transmembrane 6 Superfamily Member 1).
  • Vertebrate TM6SF2 (Transmembrane 6 Superfamily Member 2).
  • Eukaryotic MAC30 (Meningioma-associated protein 30) also known as TMEM97 (Transmembrane protein 97), mainly localized in the endoplasmic reticulum (ER).
  • Eukaryotic EBP (Emopamil binding protein), an enzyme with a D8, D7 sterol isomerase activity that catalyzes the transposition of a double bond from C8=C9 to C7=C8 in the sterol B-ring.

The EXPERA domain contains four transmembrane regions and is likely to possess a sterol isomerase catalytic activity [1].

The profile we developed covers the entire EXPERA domain.

Last update:

March 2015 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

EXPERA, PS51751; EXPERA domain profile  (MATRIX)


1AuthorsSanchez-Pulido L., Ponting C.P.
TitleTM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease.
SourceFront. Genet. 5:439-439(2014).
PubMed ID25566323

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