PROSITE documentation PDOC51751 [for PROSITE entry PS51751]
EXPERA domain profile
The EXPERA (EXPanded EBP superfamilly) domain is conserved among the following
Vertebrate TM6SF1 (Transmembrane 6 Superfamily Member 1).
Vertebrate TM6SF2 (Transmembrane 6 Superfamily Member 2).
Eukaryotic MAC30 (Meningioma-associated protein 30) also known as TMEM97
(Transmembrane protein 97), mainly localized in the endoplasmic reticulum
Eukaryotic EBP (Emopamil binding protein), an enzyme with a D8, D7 sterol
isomerase activity that catalyzes the transposition of a double bond from
C8=C9 to C7=C8 in the sterol B-ring.
The EXPERA domain contains four transmembrane regions and is likely to possess
a sterol isomerase catalytic activity [
The profile we developed covers the entire EXPERA domain.
March 2015 / First entry.
PROSITE method (with tools and information) covered by this documentation:
PS51751; EXPERA domain profile (MATRIX)
1 Authors Sanchez-Pulido L., Ponting C.P.
Title TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease.
Source Front. Genet. 5:439-439(2014).
PubMed ID 25566323
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