PROSITE documentation PDOC51752 [for PROSITE entry PS51752]Jacalin-type lectin domain profile
Lectins, a well-known class of carbohydrate-binding proteins, are known to be important in a variety of biological processes, mediated through their carbohydrate specificities. Plant lectins are broadly divided into six classes based on their subunit folds. These are legume lectins (see <PDOC00278>), jacalin-related lectins (JRLs), monocot mannose-binding lectins (see <PDOC50927>), trefoil lectins, cyanovirin-N lectin, and hevein domain lectins. JRLs derive their name from jacalin, the first member to be identified from the seed of jackfruit. Based on the known sugar specificities, lectins in this family can be broadly divided into two classes: (1) the galactose-specific lectins and (2) the mannose/glucose-specific lectins [1,2,3,4,5].
The ~135-150 amino acid residue jacalin-type lectin domain adopts a β-prism-I fold comprised of three Greek keys (four stranded β-sheets) (see <PDB:3APA>) [4].
Some proteins known to contain a jacalin-type lectin domain are listed below:
- Artocarpus integrifolia (jackfruit) jacalin.
- Artocarpus ntegrifolia (jackfruit) artocarpin.
- Morus nigra (black mulberry) mornigaG and mornigaM.
- Ipomoea batatas (sweet potato) ipomoelin (IPO).
- Musa acuminata (banana) lectin BanLec.
- Helianthus tuberosus (Jerusalem artichoke) Heltuba.
- Griffithsia sp. griffithsin.
- Mammalian zymogen granule membrane protein 16 (ZG16) and zymogen granule protein 16 homolog B (ZG16b).
The profile we developed covers the entire jacalin-type lectin domain.
Last update:March 2015 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Raval S. Gowda S.B. Singh D.D. Chandra N.R. |
| Title | A database analysis of jacalin-like lectins: sequence-structure-function relationships. | |
| Source | Glycobiology 14:1247-1263(2004). | |
| PubMed ID | 15329359 | |
| DOI | 10.1093/glycob/cwh140 |
| 2 | Authors | Rabijns A. Barre A. Van Damme E.J.M. Peumans W.J. De Ranter C.J. Rouge P. |
| Title | Structural analysis of the jacalin-related lectin MornigaM from the black mulberry (Morus nigra) in complex with mannose. | |
| Source | FEBS J. 272:3725-3732(2005). | |
| PubMed ID | 16008570 | |
| DOI | 10.1111/j.1742-4658.2005.04801.x |
| 3 | Authors | Gallego del Sol F. Nagano C. Cavada B.S. Calvete J.J. |
| Title | The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain. | |
| Source | J. Mol. Biol. 353:574-583(2005). | |
| PubMed ID | 16185708 | |
| DOI | 10.1016/j.jmb.2005.08.055 |
| 4 | Authors | Kanagawa M. Satoh T. Ikeda A. Nakano Y. Yagi H. Kato K. Kojima-Aikawa K. Yamaguchi Y. |
| Title | Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold. | |
| Source | Biochem. Biophys. Res. Commun. 404:201-205(2011). | |
| PubMed ID | 21110947 | |
| DOI | 10.1016/j.bbrc.2010.11.093 |
| 5 | Authors | Chang W.-C. Liu K.-L. Hsu F.-C. Jeng S.-T. Cheng Y.-S. |
| Title | Ipomoelin, a jacalin-related lectin with a compact tetrameric association and versatile carbohydrate binding properties regulated by its N terminus. | |
| Source | PLoS ONE 7:E40618-E40618(2012). | |
| PubMed ID | 22808208 | |
| DOI | 10.1371/journal.pone.0040618 |
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