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annotation rule: PRU00107

General rule information [?]

Accession PRU00107
Dates 12-DEC-2003 (Created)
7-JAN-2017 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS50109; HIS_KIN
Name Histidine kinase core domain
Function Autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to a phosphoacceptor.

Propagated annotation [?]

Gene Ontology [?]

GO:0016740; Molecular function: transferase activity.
GO:0016301; Molecular function: kinase activity.

Keywords [?]

case <Feature:PS50109:4=H>
end case

Features [?]

From: PS50109
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Histidine kinase #        
MOD_RES     4     4       Phosphohistidine; by autocatalysis     H  

Additional information [?]

Size range 157-356 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example P59963 (MTRB_MYCBO)
Scope Eukaryota
Comments Mitochondrial pyruvate dehydrogenase kinases (PDKs) (EC contain an histidine kinase domain which possess a serine/threonine kinase activity.


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.

UniProtKB rule member sequences [?]