Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
annotation rule: PRU00274

General rule information [?]

Accession PRU00274
Dates 12-DEC-2003 (Created)
16-DEC-2016 (Last updated, Version 18)
Data class Domain
Predictors PROSITE; PS50240; TRYPSIN_DOM
Name Serine proteases, trypsin domain
Function Cleaves preferentially: Arg-|-Xaa, Lys-|-Xaa

Propagated annotation [?]

Description [?]

case <FTGroup:1>
+ RecName: EC=3.4.21.-;
end case

Comments [?]

Similarity Belongs to the peptidase S1 family.

Cross-references [?]

case <FTGroup:1>
PS00135; TRYPSIN_SER; 1;
PS00134; TRYPSIN_HIS; 0-1;
PS00135; TRYPSIN_SER; 0-1;
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0004252; Molecular function: serine-type endopeptidase activity.

Keywords [?]

end case

case <FTTag:disulf>
end case

Features [?]

From: PS50240
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase S1 #        
ACT_SITE     42     42       Charge relay system     H   1
ACT_SITE     91     91       Charge relay system     D   1
ACT_SITE     186     186       Charge relay system     S   1
DISULFID     27     43           disulf   C-x*-C  
DISULFID     125     192           disulf   C-x*-C  
DISULFID     156     171           disulf   C-x*-C  
DISULFID     182     210           disulf   C-x*-C  

Additional information [?]

Size range 150-286 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Scope Eukaryota


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.

UniProtKB rule member sequences [?]