Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
annotation rule: PRU00333

General rule information [?]

Accession PRU00333
Dates 2-APR-2004 (Created)
16-DEC-2016 (Last updated, Version 9)
Data class Domain
Predictors PROSITE; PS50970; HCY
Name Homocysteine-binding domain
Function The homocysteine- (Hcy-)binding domain utilizes a Zn(Cys)3 cluster to bind and activate Hcy.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Cofactor Zn(2+)
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016740; Molecular function: transferase activity.
GO:0008168; Molecular function: methyltransferase activity.

Keywords [?]

end case

Features [?]

From: PS50970
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Hcy-binding #        
METAL     215     215       Zinc     C   1
METAL     281     281       Zinc     C   1
METAL     282     282       Zinc     C   1

Additional information [?]

Size range 295-330 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example Q9SDL7 (HMT1_ARATH)
Scope Eukaryota


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.

UniProtKB rule member sequences [?]