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ProRule PRU00623


General rule information [?]

Accession PRU00623
Dates 8-MAY-2008 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51292; ZF_RING_CH
Name Zinc finger RING-CH-type
Function The RING-CH-type is an E3 ligase mainly found in proteins associated to membranes.
Scope(s) Eukaryota
Viruses
Example(s) Q8TCQ1 (MARH1_HUMAN);

Propagated annotation [?]

Comments [?]

DOMAINThe RING-CH-type zinc finger domain is required for E3 ligase activity.

Keywords [?]

Ligase
Ubl conjugation pathway
Zinc-finger
case (<Feature:PS51292:9=[CH]> and <Feature:PS51292:12=[CH]> and <Feature:PS51292:36=[CH]> and <Feature:PS51292:39=[CH]>) or (<Feature:PS51292:26=[CH]> and <Feature:PS51292:28=[CH]> and <Feature:PS51292:52=[CH]> and <Feature:PS51292:55=[CH]>)
Zinc
Metal-binding
end case

Features [?]

From: PS51292
Key From To Description Tag Condition FTGroup
case (<Feature:PS51292:9=[C]> and <Feature:PS51292:12=[C]> and <Feature:PS51292:36=[H]> and <Feature:PS51292:39=[C]>) and (<Feature:PS51292:26=[C]> and <Feature:PS51292:28=[C]> and <Feature:PS51292:52=[C]> and <Feature:PS51292:55=[C]>)
ZN_FING from to /note="RING-CH-type #"
else case (<Feature:PS51292:9=[CH]> and <Feature:PS51292:12=[CH]> and <Feature:PS51292:36=[CH]> and <Feature:PS51292:39=[CH]>) and (<Feature:PS51292:26=[CH]> and <Feature:PS51292:28=[CH]> and <Feature:PS51292:52=[CH]> and <Feature:PS51292:55=[CH]>)
ZN_FING from to /note="RING-CH-type #; atypical"
else
ZN_FING from to /note="RING-CH-type #; degenerate"
end case
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
[CH] 1
BINDING 12 12 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
[CH] 1
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
[CH] 2
BINDING 28 28 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
[CH] 2
BINDING 36 36 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
[CH] 1
BINDING 39 39 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
[CH] 1
BINDING 52 52 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
[CH] 2
BINDING 55 55 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
[CH] 2

Additional information [?]

Size range 50-85 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]