PROSITE logo

ProRule PRU00679


General rule information [?]

Accession PRU00679
Dates 18-DEC-2007 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51347; PHOSPHOTRIESTERASE_2
Name Phosphotriesterase family
Function The enzyme phosphotriesterase (EC 3.1.8.1) (PTE) (also known as parathion hydrolase) belongs to a family of enzymes that possess a binuclear zinc metal center at their active site. The two zinc ions are coordinated by six different residues, four of which being histidines.
Scope(s) Eukaryota
Bacteria
Example(s) P0A433 (OPD_SPHSA);

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
end case
SIMILARITYBelongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.

Keywords [?]


Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0016787; Molecular function:hydrolase activity
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Cross-references [?]

PROSITE PS01322; PHOSPHOTRIESTERASE_1; 1;

Features [?]

From: PS51347
Key From To Description Tag Condition FTGroup
BINDING 21 21 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
H 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
H 1
BINDING 142 142 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/note="via carbamate group"
[KE] 1
BINDING 142 142 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
/note="via carbamate group"
[KE] 2
BINDING 175 175 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
H 2
BINDING 204 204 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
H 2
BINDING 263 263 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
D 1
MOD_RES 142 142 /note="N6-carboxylysine" K

Additional information [?]

Size range 280-360 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



View rule in raw text format (no links)

UniProtKB rule member sequences [?]