ProRule PRU00773
General rule information
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| Accession | PRU00773 |
| Dates | 8-APR-2009 (Created)
17-FEB-2023 (Last updated, Version 10) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51443; PCS |
Name | Phytochelatin synthase (PCS) domain |
| Function | Phytochelatins (PCs) are synthesized posttranslationally by the PC synthase (PCS) (EC 2.3.2.15), a gamma-glutamylcysteine (gamma-EC) transpeptidase. PC synthesis is proposed to have two distinct steps: (Step1) formation of gamma-EC concomitant with the cleavage of Gly from GSH; and (Step 2) transfer of the gamma-EC unit to an acceptor GSH molecule or an oligomeric PC peptide (PCn). |
| Scope(s) |
Eukaryota Bacteria Cyanobacteriota |
| Example(s) | Q2TE74 (PCS2_LOTJA); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + AltName: Full=Glutathione gamma-glutamylcysteinyltransferase; EC=2.3.2.15; |
| end case | |
Comments
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| case <FTGroup:1> | |
| CATALYTIC ACTIVITY | Reaction=[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine; Xref=Rhea:RHEA:17917, Rhea:RHEA-COMP:12438, Rhea:RHEA- COMP:12439, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:57925, ChEBI:CHEBI:131728; EC=2.3.2.15; |
| end case | |
| SIMILARITY | Belongs to the phytochelatin synthase family. |
Keywords
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| Transferase | |
| Acyltransferase | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0016756; Molecular function:glutathione gamma-glutamylcysteinyltransferase activity | |
| GO:0046938; Biological process:phytochelatin biosynthetic process | |
| GO:0016746; Molecular function:acyltransferase activity | |
Features
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| From: PS51443 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C83 #" | |||||||||
| ACT_SITE | 56 | 56 | C | 1 | ||||||||
| ACT_SITE | 168 | 168 | H | 1 | ||||||||
| ACT_SITE | 186 | 186 | D | 1 | ||||||||
Additional information
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| Size range | 210-231 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain