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annotation rule: PRU00798

General rule information [?]

Accession PRU00798
Dates 20-DEC-2011 (Created)
16-DEC-2016 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51465; KAZAL_2
Name Kazal domain
Function Kazal-type inhibitors represent the most studied canonical proteinase inhibitors.

Propagated annotation [?]

Cross-references [?]

PROSITE PS00282; KAZAL_1; 1;

Gene Ontology [?]

GO:0010466; Biological process: negative regulation of peptidase activity.
GO:0004867; Molecular function: serine-type endopeptidase inhibitor activity.

Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS51465
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Kazal-like #        
SITE     15     16       Reactive bond        
DISULFID     7     36           disulf   C-x*-C  
DISULFID     13     32           disulf   C-x*-C  
DISULFID     21     53           disulf   C-x*-C  

Additional information [?]

Size range 28-76 amino acids
Related rules None
Repeats 1-9
Topology Undefined
Example P00995 (ISK1_HUMAN)
Scope Eukaryota; Metazoa
Comments None


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to or see: prosite_license.html.

UniProtKB rule member sequences [?]