ProRule PRU00881
General rule information
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| Accession | PRU00881 |
| Dates | 23-MAR-2012 (Created)
21-NOV-2019 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51548; BIRNAVIRUS_VP4_PRO |
Name | Birnavirus VP4 protease domain |
| Function | The birnavirus VP4 protease domain displays a catalytic serine/ lysine dyad in its active site. |
| Scope(s) |
Viruses Birnaviridae |
| Example(s) | P22351 (POLS_IBDVS); |
Propagated annotation
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Comments
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| case <FTGroup:1> | |
| FUNCTION | Protease VP4 is a serine protease that cleaves the polyprotein into its final products. Pre-VP2 is first partially cleaved, and may be completely processed by VP4 upon capsid maturation. |
| end case | |
Keywords
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| Hydrolase | |
| Protease | |
| Serine protease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0016787; Molecular function:hydrolase activity | |
| GO:0008233; Molecular function:peptidase activity | |
| GO:0008236; Molecular function:serine-type peptidase activity | |
Features
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| From: PS51548 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase S50 #" | |||||||||
| ACT_SITE | 125 | 125 | /note="Nucleophile" | S | 1 | |||||||
| ACT_SITE | 163 | 163 | K | 1 | ||||||||
Additional information
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| Size range | 972-1069 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [15] All [ 15 ]
- Retrieve set of proteins with 3D structure for this domain