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ProRule PRU00944


General rule information [?]

Accession PRU00944
Dates 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51612; SAM_MT_2O_PK
Name Poxvirus/kinetoplastid ribose 2'-O-methyltransferase (EC 2.1.1.57) family
Function Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Scope(s) Viruses
Chordopoxvirinae
Example(s) P07617 (MCE_VACCW);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.-;

Comments [?]

SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. Poxvirus/kinetoplastid 2'-O-MTase family.

Keywords [?]


Features [?]

From: PS51612
Key From To Description Tag Condition FTGroup
REGION 167 246 /note="Binding to NPH-I" P-[AIV]-A-S-S-L-K-W-R-C-P-F-P-D-Q-W-I-[KR]-D-F-Y-[IV]-P-[CH]-G-[DN]-[EK]-[FM]-[LS]-Q-P-F-A-P-[PS]-[FY]-S-A-E-M-R-L-L-S-[CI]-Y-[ST]-[GR]-[AET]-[NP]-[IM]-R-L-[IKT]-[CR]-[IV]-[DT]-[KQ]-[NQS]-[AD]-[ASV]-[ISV]-[EKN]-Y-E-K-K-M-[FY]-Y-L-N-[KT]-[IK]-[IV]-R-[NP]-[KR]-[IV]-[IV]-[ILV]
BINDING 175 178 /ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"
R-C-P-F
BINDING 203 205 /ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"
S-A-E
ACT_SITE 173 173 /note="For methyltransferase activity" K
BINDING 19 19 /ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"
Y
BINDING 38 38 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
Q
BINDING 65 65 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
Y
BINDING 67 67 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
G
BINDING 71 71 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
G
BINDING 90 90 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D
BINDING 93 93 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
R
BINDING 112 112 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
V
BINDING 134 134 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D
BINDING 180 180 /ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"
D
BINDING 230 230 /ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"
E

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]