Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
annotation rule: PRU10138

General rule information [?]

Accession PRU10138
Dates 21-AUG-2009 (Created)
26-SEP-2014 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS00014; ER_TARGET
Name Endoplasmic reticulum targeting sequence
Function Proteins that permanently reside in the lumen of the endoplasmic reticulum (ER) seem to be distinguished from newly synthesized secretory proteins by the presence of the C-terminal sequence Lys-Asp-Glu-Leu (KDEL).

Propagated annotation [?]

Comments [?]

Subcellular location Endoplasmic reticulum.

Gene Ontology [?]

GO:0005783; Cellular component: endoplasmic reticulum.

Keywords [?]

Features [?]

From: PS00014
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     from     to       Prevents secretion from ER        

Additional information [?]

Size range 4 amino acids
Related rules None
Repeats 1
Topology Not cytoplasmic
Example Q9Y2B0 (CNPY2_HUMAN)
Scope Eukaryota
Comments None


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.

UniProtKB rule member sequences [?]