PROSITE documentation PDOC00099Galactokinase signature
Galactokinase (EC 2.7.1.6) [1] catalyzes the first reaction of galactose metabolism, the conversion of galactose to galactose 1-phosphate. There are three well conserved regions in the sequence of eukaryotic and prokaryotic galactokinase. As a signature pattern we have selected the best conserved of these regions, which is located in the N-terminal section of galactokinase.
In yeast the GAL3 protein [2] is required for rapid induction of the galactose system. The exact function of GAL3 is not known, but it may be involved in the production of a true inducer or coinducer molecule. The sequence of GAL3 is closely related to that of galactokinases.
Note:See also the section describing the pattern for the GHMP kinases ATP- binding domain <PDOC00545>.
Last update:July 1999 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Debouck C. Riccio A. Schumperli D. McKenney K. Jeffers J. Hughes C. Rosenberg M. Heusterspreute M. Brunel F. Davison J. |
| Title | Structure of the galactokinase gene of Escherichia coli, the last (?) gene of the gal operon. | |
| Source | Nucleic Acids Res. 13:1841-1853(1985). | |
| PubMed ID | 3158881 |
| 2 | Authors | Bajwa W. Torchia T.E. Hopper J.E. |
| Title | Yeast regulatory gene GAL3: carbon regulation; UASGal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases. | |
| Source | Mol. Cell. Biol. 8:3439-3447(1988). | |
| PubMed ID | 3062381 |
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