PROSITE documentation PDOC00099
Galactokinase signature


Galactokinase (EC [1] catalyzes the first reaction of galactose metabolism, the conversion of galactose to galactose 1-phosphate. There are three well conserved regions in the sequence of eukaryotic and prokaryotic galactokinase. As a signature pattern we have selected the best conserved of these regions, which is located in the N-terminal section of galactokinase.

In yeast the GAL3 protein [2] is required for rapid induction of the galactose system. The exact function of GAL3 is not known, but it may be involved in the production of a true inducer or coinducer molecule. The sequence of GAL3 is closely related to that of galactokinases.


See also the section describing the pattern for the GHMP kinases ATP- binding domain <PDOC00545>.

Last update:

July 1999 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

GALACTOKINASE, PS00106; Galactokinase signature  (PATTERN)


1AuthorsDebouck C. Riccio A. Schumperli D. McKenney K. Jeffers J. Hughes C. Rosenberg M. Heusterspreute M. Brunel F. Davison J.
TitleStructure of the galactokinase gene of Escherichia coli, the last (?) gene of the gal operon.
SourceNucleic Acids Res. 13:1841-1853(1985).
PubMed ID3158881

2AuthorsBajwa W. Torchia T.E. Hopper J.E.
TitleYeast regulatory gene GAL3: carbon regulation; UASGal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases.
SourceMol. Cell. Biol. 8:3439-3447(1988).
PubMed ID3062381

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