PROSITE documentation PDOC00249Channel forming colicins signature
Colicins are plasmid-encoded polypeptide toxins produced by and active against Escherichia coli and closely related bacteria. The channel-forming colicins are transmembrane proteins that depolarize the cytoplasmic membrane, leading to dissipation of cellular energy [1,2]. Colicins A, B, E1, Ia, Ib, and N belong to that group. The N-terminal part of these colicins is involved in their uptake; the central part is important for binding to outer membrane receptors and the C-terminal part is the channel-forming region.
As a signature for this type of colicins, we have selected one of the most conserved region of the channel-forming domain.
Last update:November 1990 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Pattus F. Massotte D. Wilmsen H.U. Lakey J. Tsernoglou D. Tucker A. Parker M.W. |
| Title | Colicins: prokaryotic killer-pores. | |
| Source | Experientia 46:180-192(1990). | |
| PubMed ID | 1689257 |
| 2 | Authors | Cramer W.A. Cohen F.S. Merrill A.R. Song H.Y. |
| Title | Structure and dynamics of the colicin E1 channel. | |
| Source | Mol. Microbiol. 4:519-526(1990). | |
| PubMed ID | 1693745 |
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