PROSITE documentation PDOC00249
Channel forming colicins signature


Colicins are plasmid-encoded polypeptide toxins produced by and active against Escherichia coli and closely related bacteria. The channel-forming colicins are transmembrane proteins that depolarize the cytoplasmic membrane, leading to dissipation of cellular energy [1,2]. Colicins A, B, E1, Ia, Ib, and N belong to that group. The N-terminal part of these colicins is involved in their uptake; the central part is important for binding to outer membrane receptors and the C-terminal part is the channel-forming region.

As a signature for this type of colicins, we have selected one of the most conserved region of the channel-forming domain.

Last update:

November 1990 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CHANNEL_COLICIN, PS00276; Channel forming colicins signature  (PATTERN)


1AuthorsPattus F. Massotte D. Wilmsen H.U. Lakey J. Tsernoglou D. Tucker A. Parker M.W.
TitleColicins: prokaryotic killer-pores.
SourceExperientia 46:180-192(1990).
PubMed ID1689257

2AuthorsCramer W.A. Cohen F.S. Merrill A.R. Song H.Y.
TitleStructure and dynamics of the colicin E1 channel.
SourceMol. Microbiol. 4:519-526(1990).
PubMed ID1693745

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