PROSITE documentation PDOC00265
Proliferating cell nuclear antigen signatures


Proliferating cell nuclear antigen (PCNA) [1,2] is a protein involved in DNA replication by acting as a cofactor for DNA polymerase delta, the polymerase responsible for lagging strand DNA replication.

A similar protein exists in yeast (gene POL30) [3] and is associated with polymerase III, the yeast analog of polymerase delta. In baculoviruses the ETL protein has been shown [4] to be highly related to PCNA and is probably associated with the viral encoded DNA polymerase. An homolog of PCNA is also found in archebacteria.

As signatures for this family of proteins, we selected a two conserved regions located in the N-terminal section. The second one has been proposed to bind DNA.

Last update:

January 2012 / Text revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

PCNA_1, PS01251; Proliferating cell nuclear antigen signature 1  (PATTERN)

PCNA_2, PS00293; Proliferating cell nuclear antigen signature 2  (PATTERN)


1AuthorsBravo R. Frank R. Blundell P.A. Mcdonald-Bravo H.
TitleCyclin/PCNA is the auxiliary protein of DNA polymerase-delta.
SourceNature 326:515-517(1987).
PubMed ID2882423

2AuthorsSuzuka I. Hata S. Matsuoka M. Kosugi S. Hashimoto J.
TitleHighly conserved structure of proliferating cell nuclear antigen (DNA polymerase delta auxiliary protein) gene in plants.
SourceEur. J. Biochem. 195:571-575(1991).
PubMed ID1671766

3AuthorsBauer G.A. Burgers P.M.J.
TitleMolecular cloning, structure and expression of the yeast proliferating cell nuclear antigen gene.
SourceNucleic Acids Res. 18:261-265(1990).
PubMed ID1970160

4AuthorsO'Reilly D.R. Crawford A.M. Miller L.K.
SourceNature 337:606-606(1989).

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