PROSITE documentation PDOC00265Proliferating cell nuclear antigen signatures
Proliferating cell nuclear antigen (PCNA) [1,2] is a protein involved in DNA replication by acting as a cofactor for DNA polymerase delta, the polymerase responsible for lagging strand DNA replication.
A similar protein exists in yeast (gene POL30) [3] and is associated with polymerase III, the yeast analog of polymerase delta. In baculoviruses the ETL protein has been shown [4] to be highly related to PCNA and is probably associated with the viral encoded DNA polymerase. An homolog of PCNA is also found in archebacteria.
As signatures for this family of proteins, we selected a two conserved regions located in the N-terminal section. The second one has been proposed to bind DNA.
Last update:January 2012 / Text revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Bravo R. Frank R. Blundell P.A. Mcdonald-Bravo H. |
| Title | Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. | |
| Source | Nature 326:515-517(1987). | |
| PubMed ID | 2882423 | |
| DOI | 10.1038/326515a0 |
| 2 | Authors | Suzuka I. Hata S. Matsuoka M. Kosugi S. Hashimoto J. |
| Title | Highly conserved structure of proliferating cell nuclear antigen (DNA polymerase delta auxiliary protein) gene in plants. | |
| Source | Eur. J. Biochem. 195:571-575(1991). | |
| PubMed ID | 1671766 |
| 3 | Authors | Bauer G.A. Burgers P.M.J. |
| Title | Molecular cloning, structure and expression of the yeast proliferating cell nuclear antigen gene. | |
| Source | Nucleic Acids Res. 18:261-265(1990). | |
| PubMed ID | 1970160 |
| 4 | Authors | O'Reilly D.R. Crawford A.M. Miller L.K. |
| Source | Nature 337:606-606(1989). |
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