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PROSITE documentation PDOC00296

Parathyroid hormone family signature





Description

Parathyroid hormone (PTH) is a polypeptidic hormone that elevates calcium level by dissolving the salts in bone and preventing their renal excretion. PTH is a protein of about 80 amino acid residues, but its biological activity seems to be contained within the first 34 residues.

PTH is structurally related to a protein called 'parathyroid hormone-related protein' (PTH-rP) [1] which seems to play a physiological role in lactation, possibly as a hormone for the mobilization and/or transfer of calcium to the milk. PTH-rP is a protein of 141 amino acids. As for PTH, the first 34 residues are sufficient to mediate the biological activity of PTH-rP. PTH and PTH-rP bind to the same G-protein coupled receptor.

The signature pattern we selected for these proteins is derived from conserved residues in the N-terminal extremity of PTH and PTH-rP, spanning residues 2 to 12.

Last update:

June 1992 / Text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

PARATHYROID, PS00335; Parathyroid hormone family signature  (PATTERN)


Reference

1AuthorsMartin T.J. Allan E.H. Caple I.W. Care A.D. Danks J.A. Diefenbach-Jagger H. Ebeling P.R. Gillepsie M.T. Hammonds G. Heath J.A. Hudson P.J. Kemp B.E. Kubota M. Kukreja S.C. Moseley J.M. Ng K.W. Raisz L.G. Rodda C.P. Simmons H.A. Suva L.J. Wettenhall R.E.H. Wood W.I.
TitleParathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action.
SourceRecent Prog. Horm. Res. 45:467-502(1989).
PubMed ID2682846



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