PROSITE documentation PDOC00308

Histone H2B signature

• Description
• Technical section
• References
• Copyright
• Miscellaneous

Histone H2B is one of the four histones, along with H2A, H3 and H4, which forms the eukaryotic nucleosome core. Using alignments of histone H2B sequences [1,2,E1], we selected a conserved region in the C-terminal part of H2B.

Last update:

November 1995 / Pattern and text revised.

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PROSITE method (with tools and information) covered by this documentation:

HISTONE_H2B, PS00357; Histone H2B signature  (PATTERN)

• Consensus pattern:
  [KR]-E-[LIVM]-[EQ]-T-x(2)-[KR]-x-[LIVM](2)-x-[PAG]-[DE]-L-x-[KR]-H-A-[LIVM]-[STA]-E-G
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 214
  • detected by PS00357: 192 (true positives)
  • undetected by PS00357: 22 (14 false negatives and 8 'partials')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00357:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00357
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00357
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS00357
• View ligand binding statistics of PS00357
• Matching PDB structures: 1AOI 1EQZ 1F66 1HIO ... [ALL]

1	Authors	Wells D.E. Brown D.
	Title	Histone and histone gene compilation and alignment update.
	Source	Nucleic Acids Res. 19:2173-2188(1991).
	PubMed ID	2041803

2	Authors	Thatcher T.H. Gorovsky M.A.
	Title	Phylogenetic analysis of the core histones H2A, H2B, H3, and H4.
	Source	Nucleic Acids Res. 22:174-179(1994).
	PubMed ID	8121801

E1

Title

https://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/

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