We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00349Interleukin-2 signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00349
Description
Interleukin-2 (IL-2) [1,2] is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. This protein is required for T-cell proliferation and other activities crucial to the regulation of the immune response.
The mature form of IL-2, after cleavage of the signal sequence, is a glycoprotein of about 130 amino acids that contains a single disulfide bond. A schematic representation of this structure is shown below.
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xTxxxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxx
| | |
Sugar +----------------------+
'C': conserved cysteine involved in a disulfide bond. '*': position of the pattern.Last update:
July 1998 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Smith K.A. |
| Title | Interleukin-2: inception, impact, and implications. | |
| Source | Science 240:1169-1176(1988). | |
| PubMed ID | 3131876 |
| 2 | Authors | Mizel S.B. |
| Title | The interleukins. | |
| Source | FASEB J. 3:2379-2388(1989). | |
| PubMed ID | 2676681 |
Copyright
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