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PROSITE documentation PDOC00349

Interleukin-2 signature





Description

Interleukin-2 (IL-2) [1,2] is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. This protein is required for T-cell proliferation and other activities crucial to the regulation of the immune response.

The mature form of IL-2, after cleavage of the signal sequence, is a glycoprotein of about 130 amino acids that contains a single disulfide bond. A schematic representation of this structure is shown below.

                              *******
        xTxxxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxx
         |                        |                      |
         Sugar                    +----------------------+
'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.
Last update:

July 1998 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

INTERLEUKIN_2, PS00424; Interleukin-2 signature  (PATTERN)


References

1AuthorsSmith K.A.
TitleInterleukin-2: inception, impact, and implications.
SourceScience 240:1169-1176(1988).
PubMed ID3131876

2AuthorsMizel S.B.
TitleThe interleukins.
SourceFASEB J. 3:2379-2388(1989).
PubMed ID2676681



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