We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC003906-phosphogluconate dehydrogenase signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00390
Description
6-phosphogluconate dehydrogenase (EC 1.1.1.44) (6PGD) catalyzes the third step in the hexose monophosphate shunt, the decarboxylating reduction of 6-phosphogluconate in to ribulose 5-phosphate.
Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved [1]. As a signature pattern we have selected a region which has been shown [2], from studies of the sheep 6PGD tertiary structure, to be involved in the binding of 6-phosphogluconate.
Last update:December 2004 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Reizer A. Deutscher J. Saier M.H. Jr. Reizer J. |
| Title | Analysis of the gluconate (gnt) operon of Bacillus subtilis. | |
| Source | Mol. Microbiol. 5:1081-1089(1991). | |
| PubMed ID | 1659648 |
| 2 | Authors | Adams M.J. Archibald I.G. Bugg C.E. Carne A. Gover S. Helliwell J.R. Pickersgill R.W. White S.W. |
| Title | The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution. | |
| Source | EMBO J. 2:1009-1014(1983). | |
| PubMed ID | 6641716 |
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