PROSITE documentation PDOC003906-phosphogluconate dehydrogenase signature
Description
6-phosphogluconate dehydrogenase (EC 1.1.1.44) (6PGD) catalyzes the third step in the hexose monophosphate shunt, the decarboxylating reduction of 6-phosphogluconate in to ribulose 5-phosphate.
Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved [1]. As a signature pattern we have selected a region which has been shown [2], from studies of the sheep 6PGD tertiary structure, to be involved in the binding of 6-phosphogluconate.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Reizer A. Deutscher J. Saier M.H. Jr. Reizer J. |
| Title | Analysis of the gluconate (gnt) operon of Bacillus subtilis. | |
| Source | Mol. Microbiol. 5:1081-1089(1991). | |
| PubMed ID | 1659648 |
| 2 | Authors | Adams M.J. Archibald I.G. Bugg C.E. Carne A. Gover S. Helliwell J.R. Pickersgill R.W. White S.W. |
| Title | The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution. | |
| Source | EMBO J. 2:1009-1014(1983). | |
| PubMed ID | 6641716 |
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