PROSITE documentation PDOC00390
6-phosphogluconate dehydrogenase signature


6-phosphogluconate dehydrogenase (EC (6PGD) catalyzes the third step in the hexose monophosphate shunt, the decarboxylating reduction of 6-phosphogluconate in to ribulose 5-phosphate.

Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved [1]. As a signature pattern we have selected a region which has been shown [2], from studies of the sheep 6PGD tertiary structure, to be involved in the binding of 6-phosphogluconate.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

6PGD, PS00461; 6-phosphogluconate dehydrogenase signature  (PATTERN)


1AuthorsReizer A. Deutscher J. Saier M.H. Jr. Reizer J.
TitleAnalysis of the gluconate (gnt) operon of Bacillus subtilis.
SourceMol. Microbiol. 5:1081-1089(1991).
PubMed ID1659648

2AuthorsAdams M.J. Archibald I.G. Bugg C.E. Carne A. Gover S. Helliwell J.R. Pickersgill R.W. White S.W.
TitleThe three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution.
SourceEMBO J. 2:1009-1014(1983).
PubMed ID6641716

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