PROSITE documentation PDOC00451Delta 1-pyrroline-5-carboxylate reductase signature
Description
Delta 1-pyrroline-5-carboxylate reductase (P5CR) (EC 1.5.1.2) [1,2] is the enzyme that catalyzes the terminal step in the biosynthesis of proline from glutamate, the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into proline.
The sequences of P5CR from eubacteria (gene proC), archaebacteria and eukaryotes show only a moderate level of overall similarity. As a signature pattern, we selected the best conserved region located in the C-terminal section of P5CR.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Delauney A.J. Verma D.P. |
| Title | A soybean gene encoding delta 1-pyrroline-5-carboxylate reductase was isolated by functional complementation in Escherichia coli and is found to be osmoregulated. | |
| Source | Mol. Gen. Genet. 221:299-305(1990). | |
| PubMed ID | 2199815 |
| 2 | Authors | Savioz A. Jeenes D.J. Kocher H.P. Haas D. |
| Title | Comparison of proC and other housekeeping genes of Pseudomonas aeruginosa with their counterparts in Escherichia coli. | |
| Source | Gene 86:107-111(1990). | |
| PubMed ID | 2107123 |
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