We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00451Delta 1-pyrroline-5-carboxylate reductase signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00451
Description
Delta 1-pyrroline-5-carboxylate reductase (P5CR) (EC 1.5.1.2) [1,2] is the enzyme that catalyzes the terminal step in the biosynthesis of proline from glutamate, the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into proline.
The sequences of P5CR from eubacteria (gene proC), archaebacteria and eukaryotes show only a moderate level of overall similarity. As a signature pattern, we selected the best conserved region located in the C-terminal section of P5CR.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Delauney A.J. Verma D.P. |
| Title | A soybean gene encoding delta 1-pyrroline-5-carboxylate reductase was isolated by functional complementation in Escherichia coli and is found to be osmoregulated. | |
| Source | Mol. Gen. Genet. 221:299-305(1990). | |
| PubMed ID | 2199815 |
| 2 | Authors | Savioz A. Jeenes D.J. Kocher H.P. Haas D. |
| Title | Comparison of proC and other housekeeping genes of Pseudomonas aeruginosa with their counterparts in Escherichia coli. | |
| Source | Gene 86:107-111(1990). | |
| PubMed ID | 2107123 |
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