PROSITE documentation PDOC00451
Delta 1-pyrroline-5-carboxylate reductase signature


Delta 1-pyrroline-5-carboxylate reductase (P5CR) (EC [1,2] is the enzyme that catalyzes the terminal step in the biosynthesis of proline from glutamate, the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into proline.

The sequences of P5CR from eubacteria (gene proC), archaebacteria and eukaryotes show only a moderate level of overall similarity. As a signature pattern, we selected the best conserved region located in the C-terminal section of P5CR.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

P5CR, PS00521; Delta 1-pyrroline-5-carboxylate reductase signature  (PATTERN)


1AuthorsDelauney A.J. Verma D.P.
TitleA soybean gene encoding delta 1-pyrroline-5-carboxylate reductase was isolated by functional complementation in Escherichia coli and is found to be osmoregulated.
SourceMol. Gen. Genet. 221:299-305(1990).
PubMed ID2199815

2AuthorsSavioz A. Jeenes D.J. Kocher H.P. Haas D.
TitleComparison of proC and other housekeeping genes of Pseudomonas aeruginosa with their counterparts in Escherichia coli.
SourceGene 86:107-111(1990).
PubMed ID2107123

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