We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00500Ribosomal protein S6e signature
View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC00500
Description
A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists of:
- Mammalian S6 [1].
- Drosophila S6 [2].
- Plant S6 [3].
- Yeast S10 (YS4).
- Halobacterium marismortui HS13 [4].
- Methanococcus jannaschii MJ1260.
S6 is the major substrate of protein kinases in eukaryotic ribosomes [5]; it may have an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
These proteins have 135 to 249 amino acids. As a signature pattern, we selected a conserved stretch of 12 residues in the N-terminal part of these proteins.
Expert(s) to contact by email: Last update:December 2004 / Pattern and text revised.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Franco R. Rosenfeld M.G. |
| Title | Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6. | |
| Source | J. Biol. Chem. 265:4321-4325(1990). | |
| PubMed ID | 2106518 |
| 2 | Authors | Watson K.L. Konrad K.D. Woods D.F. Bryant P.J. |
| Title | Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:11302-11306(1992). | |
| PubMed ID | 1454811 |
| 3 | Authors | Hansen G. Estruch J.J. Spena A. |
| Title | Tobacco cDNA encoding the ribosomal protein S6. | |
| Source | Nucleic Acids Res. 20:5230-5230(1992). | |
| PubMed ID | 1408841 |
| 4 | Authors | Kimura M. Arndt E. Hatakeyama T. Hatakeyama T. Kimura J. |
| Title | Ribosomal proteins in halobacteria. | |
| Source | Can. J. Microbiol. 35:195-199(1989). | |
| PubMed ID | 2655851 |
| 5 | Authors | Bandi H.R. Ferrari S. Krieg J. Meyer H.E. Thomas G. |
| Title | Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum. | |
| Source | J. Biol. Chem. 268:4530-4533(1993). | |
| PubMed ID | 8440735 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.