PROSITE documentation PDOC00500Ribosomal protein S6e signature
Description
A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists of:
- Mammalian S6 [1].
- Drosophila S6 [2].
- Plant S6 [3].
- Yeast S10 (YS4).
- Halobacterium marismortui HS13 [4].
- Methanococcus jannaschii MJ1260.
S6 is the major substrate of protein kinases in eukaryotic ribosomes [5]; it may have an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
These proteins have 135 to 249 amino acids. As a signature pattern, we selected a conserved stretch of 12 residues in the N-terminal part of these proteins.
Expert(s) to contact by email: Last update:December 2004 / Pattern and text revised.
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References
| 1 | Authors | Franco R. Rosenfeld M.G. |
| Title | Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6. | |
| Source | J. Biol. Chem. 265:4321-4325(1990). | |
| PubMed ID | 2106518 |
| 2 | Authors | Watson K.L. Konrad K.D. Woods D.F. Bryant P.J. |
| Title | Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:11302-11306(1992). | |
| PubMed ID | 1454811 |
| 3 | Authors | Hansen G. Estruch J.J. Spena A. |
| Title | Tobacco cDNA encoding the ribosomal protein S6. | |
| Source | Nucleic Acids Res. 20:5230-5230(1992). | |
| PubMed ID | 1408841 |
| 4 | Authors | Kimura M. Arndt E. Hatakeyama T. Hatakeyama T. Kimura J. |
| Title | Ribosomal proteins in halobacteria. | |
| Source | Can. J. Microbiol. 35:195-199(1989). | |
| PubMed ID | 2655851 |
| 5 | Authors | Bandi H.R. Ferrari S. Krieg J. Meyer H.E. Thomas G. |
| Title | Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum. | |
| Source | J. Biol. Chem. 268:4530-4533(1993). | |
| PubMed ID | 8440735 |
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