PROSITE documentation PDOC00500
Ribosomal protein S6e signature


A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists of:

  • Mammalian S6 [1].
  • Drosophila S6 [2].
  • Plant S6 [3].
  • Yeast S10 (YS4).
  • Halobacterium marismortui HS13 [4].
  • Methanococcus jannaschii MJ1260.

S6 is the major substrate of protein kinases in eukaryotic ribosomes [5]; it may have an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

These proteins have 135 to 249 amino acids. As a signature pattern, we selected a conserved stretch of 12 residues in the N-terminal part of these proteins.

Expert(s) to contact by email:

Thomas G.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_S6E, PS00578; Ribosomal protein S6e signature  (PATTERN)


1AuthorsFranco R. Rosenfeld M.G.
TitleHormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6.
SourceJ. Biol. Chem. 265:4321-4325(1990).
PubMed ID2106518

2AuthorsWatson K.L. Konrad K.D. Woods D.F. Bryant P.J.
TitleDrosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system.
SourceProc. Natl. Acad. Sci. U.S.A. 89:11302-11306(1992).
PubMed ID1454811

3AuthorsHansen G. Estruch J.J. Spena A.
TitleTobacco cDNA encoding the ribosomal protein S6.
SourceNucleic Acids Res. 20:5230-5230(1992).
PubMed ID1408841

4AuthorsKimura M. Arndt E. Hatakeyama T. Hatakeyama T. Kimura J.
TitleRibosomal proteins in halobacteria.
SourceCan. J. Microbiol. 35:195-199(1989).
PubMed ID2655851

5AuthorsBandi H.R. Ferrari S. Krieg J. Meyer H.E. Thomas G.
TitleIdentification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum.
SourceJ. Biol. Chem. 268:4530-4533(1993).
PubMed ID8440735

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