Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00583Electron transfer flavoprotein alpha-subunit signature
View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC00583
The electron transfer flavoprotein (ETF) [1,2] serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consist of an α and a β subunit and which bind one molecule of FAD per dimer. A similar system also exists in some bacteria.
The α subunit of ETF is a protein of about 32 Kd which is structurally related to the bacterial nitrogen fixation protein fixB which could play a role in a redox process and feed electrons to ferredoxin.
Other related proteins are:
- Escherichia coli hypothetical protein ydiR.
- Escherichia coli hypothetical protein ygcQ.
As a signature pattern for these proteins we selected a highly conserved region which is located in the C-terminal section.
Last update:December 2004 / Pattern and text revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Finocchiaro G. Ikeda Y. Ito M. Tanaka K. |
| Title | Biosynthesis, molecular cloning and sequencing of electron transfer flavoprotein. | |
| Source | Prog. Clin. Biol. Res. 321:637-652(1990). | |
| PubMed ID | 2326318 |
| 2 | Authors | Tsai M.H. Saier M.H. Jr. |
| Title | Phylogenetic characterization of the ubiquitous electron transfer flavoprotein families ETF-alpha and ETF-beta. | |
| Source | Res. Microbiol. 146:397-404(1995). | |
| PubMed ID | 8525056 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.