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PROSITE documentation PDOC00583

Electron transfer flavoprotein alpha-subunit signature





Description

The electron transfer flavoprotein (ETF) [1,2] serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consist of an α and a β subunit and which bind one molecule of FAD per dimer. A similar system also exists in some bacteria.

The α subunit of ETF is a protein of about 32 Kd which is structurally related to the bacterial nitrogen fixation protein fixB which could play a role in a redox process and feed electrons to ferredoxin.

Other related proteins are:

  • Escherichia coli hypothetical protein ydiR.
  • Escherichia coli hypothetical protein ygcQ.

As a signature pattern for these proteins we selected a highly conserved region which is located in the C-terminal section.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

ETF_ALPHA, PS00696; Electron transfer flavoprotein alpha-subunit signature  (PATTERN)


References

1AuthorsFinocchiaro G. Ikeda Y. Ito M. Tanaka K.
TitleBiosynthesis, molecular cloning and sequencing of electron transfer flavoprotein.
SourceProg. Clin. Biol. Res. 321:637-652(1990).
PubMed ID2326318

2AuthorsTsai M.H. Saier M.H. Jr.
TitlePhylogenetic characterization of the ubiquitous electron transfer flavoprotein families ETF-alpha and ETF-beta.
SourceRes. Microbiol. 146:397-404(1995).
PubMed ID8525056



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