PROSITE documentation PDOC00583Electron transfer flavoprotein alpha-subunit signature
The electron transfer flavoprotein (ETF) [1,2] serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consist of an α and a β subunit and which bind one molecule of FAD per dimer. A similar system also exists in some bacteria.
The α subunit of ETF is a protein of about 32 Kd which is structurally related to the bacterial nitrogen fixation protein fixB which could play a role in a redox process and feed electrons to ferredoxin.
Other related proteins are:
- Escherichia coli hypothetical protein ydiR.
- Escherichia coli hypothetical protein ygcQ.
As a signature pattern for these proteins we selected a highly conserved region which is located in the C-terminal section.
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Finocchiaro G. Ikeda Y. Ito M. Tanaka K. |
| Title | Biosynthesis, molecular cloning and sequencing of electron transfer flavoprotein. | |
| Source | Prog. Clin. Biol. Res. 321:637-652(1990). | |
| PubMed ID | 2326318 |
| 2 | Authors | Tsai M.H. Saier M.H. Jr. |
| Title | Phylogenetic characterization of the ubiquitous electron transfer flavoprotein families ETF-alpha and ETF-beta. | |
| Source | Res. Microbiol. 146:397-404(1995). | |
| PubMed ID | 8525056 |
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