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PROSITE documentation PDOC00667 |
Tryptophan indole-lyase (EC 4.1.99.1) (tryptophanase) and tyrosine phenol-lyase (EC 4.1.99.2) (β-tyrosinase) are related pyridoxal-phosphate dependent homotetrameric enzymes [1]. Tryptophan indole-lyase catalyzes the transformation of tryptophan into indole, pyruvate and ammonia and tyrosine phenol-lyase transforms tyrosine into phenol, pyruvate and ammonia.
Both enzymes are proteins that contains 450 to 470 amino acids. The pyridoxal-phosphate group is attached to a lysine residue in the central section of the sequence.
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Iwamori S. Yoshino S. Ishiwata K. Makiguchi N. |
Source | J. Ferment. Bioeng. 72:147-151(1991). |