PROSITE logo

PROSITE documentation PDOC00667
Beta-eliminating lyases pyridoxal-phosphate attachment site


Description

Tryptophan indole-lyase (EC 4.1.99.1) (tryptophanase) and tyrosine phenol-lyase (EC 4.1.99.2) (β-tyrosinase) are related pyridoxal-phosphate dependent homotetrameric enzymes [1]. Tryptophan indole-lyase catalyzes the transformation of tryptophan into indole, pyruvate and ammonia and tyrosine phenol-lyase transforms tyrosine into phenol, pyruvate and ammonia.

Both enzymes are proteins that contains 450 to 470 amino acids. The pyridoxal-phosphate group is attached to a lysine residue in the central section of the sequence.

Last update:

December 2004 / Pattern and text revised.

-------------------------------------------------------------------------------


Technical section

PROSITE method (with tools and information) covered by this documentation:

BETA_ELIM_LYASE, PS00853; Beta-eliminating lyases pyridoxal-phosphate attachment site  (PATTERN)


Reference

1AuthorsIwamori S. Yoshino S. Ishiwata K. Makiguchi N.
SourceJ. Ferment. Bioeng. 72:147-151(1991).



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)