PROSITE documentation PDOC00682
Bacterial type II secretion system protein F signature


A number of bacterial proteins, some of which are involved in a general secretion pathway (GSP) for the export of proteins (also called the type II pathway) [1], have been found to be evolutionary related. These proteins are listed below.

  • The 'F' protein from the GSP operon of: Aeromonas (gene exeF); Erwinia (gene outF); Escherichia coli (gene hofF); Klebsiella pneumoniae (gene pulF); Pseudomonas aeruginosa (gene xcpS); Vibrio cholerae (gene epsF) and Xanthomonas campestris (gene xpsF).
  • Bacillus subtilis comG operon protein 2 which is required for the uptake of DNA by competent Bacillus subtilis cells.
  • Aeromonas hydrophila tapC, involved in type IV pilus assembly.
  • Pseudomonas protein pilC, which is essential for the formation of the pili.
  • Vibrio cholerae protein tcpE, which is involved in the biosynthesis of the tcp pilus.
  • Escherichia coli protein hofC (hopC).

These are proteins of about 400 amino acids that are highly hydrophobic and which are thought to be integral protein of the inner membrane. As a signature pattern we selected a conserved region in the central part of these proteins.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

T2SP_F, PS00874; Bacterial type II secretion system protein F signature  (PATTERN)


1AuthorsSalmond G.P.C. Reeves P.J.
TitleMembrane traffic wardens and protein secretion in gram-negative bacteria.
SourceTrends Biochem. Sci. 18:7-12(1993).
PubMed ID8438237

2AuthorsHobbs M. Mattick J.S.
TitleCommon components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes.
SourceMol. Microbiol. 10:233-243(1993).
PubMed ID7934814

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