We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00709Syntaxin / epimorphin family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00709
Description
The following proteins have been shown to be evolutionary related [1,2,3]:
- Epimorphin (or syntaxin 2), a mammalian mesenchymal protein which plays an essential role in epithelial morphogenesis.
- Syntaxin 1A (also known as antigen HPC-1) and syntaxin 1B which are synaptic proteins which may be involved in docking of synaptic vesicles at presynaptic active zones.
- Syntaxin 3.
- Syntaxin 4, which is potentially involved in docking of synaptic vesicles at presynaptic active zones.
- Syntaxin 5, which mediates endoplasmic reticulum to golgi transport.
- Syntaxin 6, which is involved in intracellular vesicle trafficking.
- Syntaxin 7.
- Yeast PEP12 (or VPS6) which is required for the transport of proteases to the vacuole.
- Yeast SED5 which is required for the fusion of transport vesicles with the Golgi complex.
- Yeast SSO1 and SSO2 which are required for vesicle fusion with the plasma membrane.
- Yeast VAM3, which is required for vacuolar assembly.
- Arabidopsis thaliana protein KNOLLE which may be involved in cytokinesis.
- Caenorhabditis elegans hypothetical proteins F35C8.4, F48F7.2, F55A11.2 and T01B11.3.
The above proteins share the following characteristics: a size ranging from 30 Kd to 40 Kd; a C-terminal extremity which is highly hydrophobic and is probably involved in anchoring the protein to the membrane; a central, well conserved region, which seems to be in a coiled-coil conformation.
The pattern specific for this family is based on the most conserved region of the coiled coil domain.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Bennett M.K. Garcia-Arraras J.E. Elferink L.A. Peterson K. Fleming A.M. Hazuka C.D. Scheller R.H. |
| Title | The syntaxin family of vesicular transport receptors. | |
| Source | Cell 74:863-873(1993). | |
| PubMed ID | 7690687 |
| 2 | Authors | Spring J. Kato M. Bernfield M. |
| Title | Epimorphin is related to a new class of neuronal and yeast vesicle targeting proteins. | |
| Source | Trends Biochem. Sci. 18:124-125(1993). | |
| PubMed ID | 8493722 |
| 3 | Authors | Pelham H.R.B. |
| Title | Is epimorphin involved in vesicular transport? | |
| Source | Cell 73:425-426(1993). | |
| PubMed ID | 8490959 |
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