PROSITE documentation PDOC00709
Syntaxin / epimorphin family signature


The following proteins have been shown to be evolutionary related [1,2,3]:

  • Epimorphin (or syntaxin 2), a mammalian mesenchymal protein which plays an essential role in epithelial morphogenesis.
  • Syntaxin 1A (also known as antigen HPC-1) and syntaxin 1B which are synaptic proteins which may be involved in docking of synaptic vesicles at presynaptic active zones.
  • Syntaxin 3.
  • Syntaxin 4, which is potentially involved in docking of synaptic vesicles at presynaptic active zones.
  • Syntaxin 5, which mediates endoplasmic reticulum to golgi transport.
  • Syntaxin 6, which is involved in intracellular vesicle trafficking.
  • Syntaxin 7.
  • Yeast PEP12 (or VPS6) which is required for the transport of proteases to the vacuole.
  • Yeast SED5 which is required for the fusion of transport vesicles with the Golgi complex.
  • Yeast SSO1 and SSO2 which are required for vesicle fusion with the plasma membrane.
  • Yeast VAM3, which is required for vacuolar assembly.
  • Arabidopsis thaliana protein KNOLLE which may be involved in cytokinesis.
  • Caenorhabditis elegans hypothetical proteins F35C8.4, F48F7.2, F55A11.2 and T01B11.3.

The above proteins share the following characteristics: a size ranging from 30 Kd to 40 Kd; a C-terminal extremity which is highly hydrophobic and is probably involved in anchoring the protein to the membrane; a central, well conserved region, which seems to be in a coiled-coil conformation.

The pattern specific for this family is based on the most conserved region of the coiled coil domain.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SYNTAXIN, PS00914; Syntaxin / epimorphin family signature  (PATTERN)


1AuthorsBennett M.K. Garcia-Arraras J.E. Elferink L.A. Peterson K. Fleming A.M. Hazuka C.D. Scheller R.H.
TitleThe syntaxin family of vesicular transport receptors.
SourceCell 74:863-873(1993).
PubMed ID7690687

2AuthorsSpring J. Kato M. Bernfield M.
TitleEpimorphin is related to a new class of neuronal and yeast vesicle targeting proteins.
SourceTrends Biochem. Sci. 18:124-125(1993).
PubMed ID8493722

3AuthorsPelham H.R.B.
TitleIs epimorphin involved in vesicular transport?
SourceCell 73:425-426(1993).
PubMed ID8490959

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