PROSITE documentation PDOC00718
Yeast PIR proteins repeats signature and profile


A number of yeast cell wall glycoproteins are characterized by the presence of tandem repeats of a region of 18 to 19 residues [1,2,3]. These proteins are:

  • CCW7 (9 repeats).
  • CCW11 (1 repeat).
  • CWP2 or LPR1.
  • PIR1 or CCW6 (8 repeats).
  • PIR2 or HSP150 (11 repeats).
  • PIR3 or CCW8 (10 repeats).
  • TIR1 or SRP1 (1 repeat) (see <PDOC00596>).
  • TIR2 or SRP2 (1 repeat) (see <PDOC00596>).
  • Hypothetical protein YHR126c (1 repeat).
  • Hypothetical protein YJL160c (4 repeats).

The core region of the repeat is highly conserved and is used here as a signature pattern. We also developed a profile that spans the complete repeat.

Last update:

December 2001 / Text revised; profile added.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

PIR_REPEAT_2, PS50256; Yeast PIR proteins repeats profile  (MATRIX)

PIR_REPEAT_1, PS00929; Yeast PIR proteins repeats signature  (PATTERN)


1AuthorsToh-E A. Yasunaga S. Nisogi H. Tanaka K. Oguchi T. Matsui Y.
SourceYeast 9:481-494(1993).

2AuthorsBairoch A.
SourceUnpublished observations (1994).

3AuthorsMrsa V. Seidl T. Gentzsch M. Tanner W.
TitleSpecific labelling of cell wall proteins by biotinylation. Identification of four covalently linked O-mannosylated proteins of Saccharomyces cerevisiae.
SourceYeast 13:1145-1154(1997).
PubMed ID9301021

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