PROSITE documentation PDOC00726
glpT family of transporters signature


The following proteins involved in the uptake of phosphorylated metabolites, are evolutionary related [1,2]:

  • Escherichia coli, Bacillus subtilis and Haemophilus influenzae glycerol-3- phosphate transporter (gene glpT).
  • Salmonella typhimurium phosphoglycerate transporter (gene pgtP).
  • Escherichia coli and Salmonella typhimurium hexose-6-phosphate transporter (gene uhpT).
  • Escherichia coli and Salmonella typhimurium protein uhpC. UhpC is necessary for the expression of uhpT and seems to act jointly with the uhpB sensor/ kinase protein.
  • Human glucose 6-phosphate translocase [3].

These proteins of about 50 Kd apparently contain 12 transmembrane regions. As a signature pattern we selected a conserved region in their central section.

Last update:

July 1999 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

GLPT, PS00942; glpT family of transporters signature  (PATTERN)


1AuthorsGoldrick D. Yu G.-Q. Jiang S.-Q. Hong J.S.
TitleNucleotide sequence and transcription start point of the phosphoglycerate transporter gene of Salmonella typhimurium.
SourceJ. Bacteriol. 170:3421-3426(1988).
PubMed ID3042749

2AuthorsMarger M.D. Saier M.H. Jr.
TitleA major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.
SourceTrends Biochem. Sci. 18:13-20(1993).
PubMed ID8438231

3AuthorsGerin I. Veiga-da-Cunha M. Achouri Y. Collet J.-F. Van Schaftingen E.
TitleSequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib.
SourceFEBS Lett. 419:235-238(1997).
PubMed ID9428641

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