PROSITE documentation PDOC00726glpT family of transporters signature
Description
The following proteins involved in the uptake of phosphorylated metabolites, are evolutionary related [1,2]:
- Escherichia coli, Bacillus subtilis and Haemophilus influenzae glycerol-3- phosphate transporter (gene glpT).
- Salmonella typhimurium phosphoglycerate transporter (gene pgtP).
- Escherichia coli and Salmonella typhimurium hexose-6-phosphate transporter (gene uhpT).
- Escherichia coli and Salmonella typhimurium protein uhpC. UhpC is necessary for the expression of uhpT and seems to act jointly with the uhpB sensor/ kinase protein.
- Human glucose 6-phosphate translocase [3].
These proteins of about 50 Kd apparently contain 12 transmembrane regions. As a signature pattern we selected a conserved region in their central section.
Last update:July 1999 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Goldrick D. Yu G.-Q. Jiang S.-Q. Hong J.S. |
| Title | Nucleotide sequence and transcription start point of the phosphoglycerate transporter gene of Salmonella typhimurium. | |
| Source | J. Bacteriol. 170:3421-3426(1988). | |
| PubMed ID | 3042749 |
| 2 | Authors | Marger M.D. Saier M.H. Jr. |
| Title | A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. | |
| Source | Trends Biochem. Sci. 18:13-20(1993). | |
| PubMed ID | 8438231 |
| 3 | Authors | Gerin I. Veiga-da-Cunha M. Achouri Y. Collet J.-F. Van Schaftingen E. |
| Title | Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib. | |
| Source | FEBS Lett. 419:235-238(1997). | |
| PubMed ID | 9428641 |
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