We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00726glpT family of transporters signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00726
Description
The following proteins involved in the uptake of phosphorylated metabolites, are evolutionary related [1,2]:
- Escherichia coli, Bacillus subtilis and Haemophilus influenzae glycerol-3- phosphate transporter (gene glpT).
- Salmonella typhimurium phosphoglycerate transporter (gene pgtP).
- Escherichia coli and Salmonella typhimurium hexose-6-phosphate transporter (gene uhpT).
- Escherichia coli and Salmonella typhimurium protein uhpC. UhpC is necessary for the expression of uhpT and seems to act jointly with the uhpB sensor/ kinase protein.
- Human glucose 6-phosphate translocase [3].
These proteins of about 50 Kd apparently contain 12 transmembrane regions. As a signature pattern we selected a conserved region in their central section.
Last update:July 1999 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Goldrick D. Yu G.-Q. Jiang S.-Q. Hong J.S. |
| Title | Nucleotide sequence and transcription start point of the phosphoglycerate transporter gene of Salmonella typhimurium. | |
| Source | J. Bacteriol. 170:3421-3426(1988). | |
| PubMed ID | 3042749 |
| 2 | Authors | Marger M.D. Saier M.H. Jr. |
| Title | A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. | |
| Source | Trends Biochem. Sci. 18:13-20(1993). | |
| PubMed ID | 8438231 |
| 3 | Authors | Gerin I. Veiga-da-Cunha M. Achouri Y. Collet J.-F. Van Schaftingen E. |
| Title | Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib. | |
| Source | FEBS Lett. 419:235-238(1997). | |
| PubMed ID | 9428641 |
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