PROSITE documentation PDOC00755
Bacterial-type phytoene dehydrogenase signature


Phytoene dehydrogenase (phytoene desaturase) is an enzyme of carotenoid biosynthesis that converts phytoene into zeta-carotene via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene. The sequence of phytoene dehydrogenase from bacteria (gene crtI or carC) and fungi (gene AL-1) are not related to that from cyanobacteria and plants but is evolutionary related [1] to that of another enzyme of carotenoid biosynthesis, methoxyneurosporene dehydrogenase (gene crtD).

There are two glycine-rich conserved regions, both of which probably play a role in the binding of either FAD or NAD. The first conserved region is in the N-terminal section while the second one is in the C-terminal section. We have used the second region as a signature pattern.

Last update:

November 1997 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PHYTOENE_DH, PS00982; Bacterial-type phytoene dehydrogenase signature  (PATTERN)


1AuthorsBartley G.E. Schmidhauser T.J. Yanofsky C. Scolnik P.A.
TitleCarotenoid desaturases from Rhodobacter capsulatus and Neurospora crassa are structurally and functionally conserved and contain domains homologous to flavoprotein disulfide oxidoreductases.
SourceJ. Biol. Chem. 265:16020-16024(1990).
PubMed ID2144293

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