PROSITE documentation PDOC00755Bacterial-type phytoene dehydrogenase signature
Phytoene dehydrogenase (phytoene desaturase) is an enzyme of carotenoid biosynthesis that converts phytoene into zeta-carotene via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene. The sequence of phytoene dehydrogenase from bacteria (gene crtI or carC) and fungi (gene AL-1) are not related to that from cyanobacteria and plants but is evolutionary related [1] to that of another enzyme of carotenoid biosynthesis, methoxyneurosporene dehydrogenase (gene crtD).
There are two glycine-rich conserved regions, both of which probably play a role in the binding of either FAD or NAD. The first conserved region is in the N-terminal section while the second one is in the C-terminal section. We have used the second region as a signature pattern.
Last update:November 1997 / Pattern and text revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Bartley G.E. Schmidhauser T.J. Yanofsky C. Scolnik P.A. |
| Title | Carotenoid desaturases from Rhodobacter capsulatus and Neurospora crassa are structurally and functionally conserved and contain domains homologous to flavoprotein disulfide oxidoreductases. | |
| Source | J. Biol. Chem. 265:16020-16024(1990). | |
| PubMed ID | 2144293 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)