PROSITE documentation PDOC00774Oxysterol-binding protein family signature
Description
A number of eukaryotic proteins that seem to be involved with sterol synthesis and/or its regulation have been found [1] to be evolutionary related:
- Mammalian oxysterol-binding protein (OSBP). A protein of about 800 amino- acid residues that binds a variety of oxysterols: oxygenated derivatives of cholesterol. OSBP seems to play a complex role in the regulation of sterol metabolism.
- Mammalian OSBP-related proteins 1 to 11.
- Yeast proteins HES1 and KES1; highly related proteins of 434 residues that seem to play a role in ergosterol synthesis.
- Yeast OSH1 to OSH7.
All these proteins contain a moderately conserved domain of about 250 residues located in the C-terminal half of OBSP, OSH1 and YHR073w and in the central section of the other proteins. As a signature pattern, we selected the best conserved part of this domain, a region that contains a conserved pentapeptide.
Last update:April 2006 / Pattern revised.
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Reference
1 | Authors | Jiang B. Brown J.L. Sheraton J. Fortin N. Bussey H. |
Title | A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. | |
Source | Yeast 10:341-353(1994). | |
PubMed ID | 8017104 |
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