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PROSITE documentation PDOC00774 |
A number of eukaryotic proteins that seem to be involved with sterol synthesis and/or its regulation have been found [1] to be evolutionary related:
All these proteins contain a moderately conserved domain of about 250 residues located in the C-terminal half of OBSP, OSH1 and YHR073w and in the central section of the other proteins. As a signature pattern, we selected the best conserved part of this domain, a region that contains a conserved pentapeptide.
Last update:April 2006 / Pattern revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Jiang B. Brown J.L. Sheraton J. Fortin N. Bussey H. |
Title | A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. | |
Source | Yeast 10:341-353(1994). | |
PubMed ID | 8017104 |