PROSITE documentation PDOC00836
TatD deoxyribonuclease family


The Escherichia coli protein tatD is a cytoplasmic protein with magnesium-dependent DNase activity [1]. It is similar to a number of proteins in all three kingdoms of life, among which:

  • Yeast chromosome II hypothetical protein YBL055c.
  • Escherichia coli hypothetical protein ycfH and HI0454, the corresponding Haemophilus influenzae protein.
  • Escherichia coli hypothetical protein yjjV and HI0081, the corresponding Haemophilus influenzae protein.
  • Bacillus subtilis hypothetical protein yabD.
  • Haemophilus influenzae hypothetical protein HI1664.
  • Mycoplasma genitalium hypothetical protein MG009.

These are proteins of from 24 to 47 Kd which contain a number of conserved regions. They can be picked up in the database by the following patterns.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

TATD_1, PS01137; TatD deoxyribonuclease family signature 1  (PATTERN)

TATD_2, PS01090; TatD deoxyribonuclease family signature 2  (PATTERN)

TATD_3, PS01091; TatD deoxyribonuclease family signature 3  (PATTERN)


1AuthorsWexler M. Sargent F. Jack R.L. Stanley N.R. Bogsch E.G. Robinson C. Berks B.C. Palmer T.
TitleTatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
SourceJ. Biol. Chem. 275:16717-16722(2000).
PubMed ID10747959

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