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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE documentation PDOC00888
NOL1/NOP2/sun family signature


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PURL: https://purl.expasy.org/prosite/documentation/PDOC00888

Description

The following proteins seems to be evolutionary related:

  • Mammalian proliferating-cell nucleolar antigen p120 (gene NOL1) which may play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.
  • Yeast nucleolar protein NOP2 (or YNA1) which could be involved in nucleolar function during the onset of growth, and in the maintenance of nucleolar structure.
  • Yeast hypothetical protein YBL024w.
  • Bacterial protein sun (also known as fmu).
  • Escherichia coli hypothetical protein yebU.
  • Mycobacterium tuberculosis hypothetical protein MtCY21B4.24.
  • Methanococcus jannaschii hypothetical protein MJ0026.

NOL1 is a protein of 855 residues, NOP2 consists of 618 residues, YBL024w of 684, sun is a protein of about 430 to 450 residues and MJ026 has 274 residues. They share a conserved central domain which contains some highly conserved regions. We have selected one these regions as a signature pattern.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

NOL1_NOP2_SUN, PS01153; NOL1/NOP2/sun family signature  (PATTERN)


Reference



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