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PROSITE documentation PDOC00888

NOL1/NOP2/sun family signature





Description

The following proteins seems to be evolutionary related:

  • Mammalian proliferating-cell nucleolar antigen p120 (gene NOL1) which may play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.
  • Yeast nucleolar protein NOP2 (or YNA1) which could be involved in nucleolar function during the onset of growth, and in the maintenance of nucleolar structure.
  • Yeast hypothetical protein YBL024w.
  • Bacterial protein sun (also known as fmu).
  • Escherichia coli hypothetical protein yebU.
  • Mycobacterium tuberculosis hypothetical protein MtCY21B4.24.
  • Methanococcus jannaschii hypothetical protein MJ0026.

NOL1 is a protein of 855 residues, NOP2 consists of 618 residues, YBL024w of 684, sun is a protein of about 430 to 450 residues and MJ026 has 274 residues. They share a conserved central domain which contains some highly conserved regions. We have selected one these regions as a signature pattern.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

NOL1_NOP2_SUN, PS01153; NOL1/NOP2/sun family signature  (PATTERN)


Reference



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