PROSITE documentation PDOC00983Ribonuclease PH signature
Description
Prokaryotic ribonuclease PH (EC 2.7.7.56) (RNase PH) [1] is a phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.
RNase PH is a conserved protein of about 240 amino-acid residues. It is evolutionary related to Caenorhabditis elegans hypothetical protein B0564.1.
As a signature pattern, we selected the most highly conserved region which is located in the central part of these proteins.
Last update:April 2006 / Pattern revised.
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Technical section
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Reference
| 1 | Authors | Kelly K.O. Deutscher M.P. |
| Title | Characterization of Escherichia coli RNase PH. | |
| Source | J. Biol. Chem. 267:17153-17158(1992). | |
| PubMed ID | 1512253 |
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