We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00983Ribonuclease PH signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00983
Description
Prokaryotic ribonuclease PH (EC 2.7.7.56) (RNase PH) [1] is a phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.
RNase PH is a conserved protein of about 240 amino-acid residues. It is evolutionary related to Caenorhabditis elegans hypothetical protein B0564.1.
As a signature pattern, we selected the most highly conserved region which is located in the central part of these proteins.
Last update:April 2006 / Pattern revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Kelly K.O. Deutscher M.P. |
| Title | Characterization of Escherichia coli RNase PH. | |
| Source | J. Biol. Chem. 267:17153-17158(1992). | |
| PubMed ID | 1512253 |
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