PROSITE documentation PDOC00983
Ribonuclease PH signature


Prokaryotic ribonuclease PH (EC (RNase PH) [1] is a phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.

RNase PH is a conserved protein of about 240 amino-acid residues. It is evolutionary related to Caenorhabditis elegans hypothetical protein B0564.1.

As a signature pattern, we selected the most highly conserved region which is located in the central part of these proteins.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBONUCLEASE_PH, PS01277; Ribonuclease PH signature  (PATTERN)


1AuthorsKelly K.O. Deutscher M.P.
TitleCharacterization of Escherichia coli RNase PH.
SourceJ. Biol. Chem. 267:17153-17158(1992).
PubMed ID1512253

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