PROSITE documentation PDOC01019

Phosphatidate cytidylyltransferase signature


Phosphatidate cytidylyltransferase (EC [1,2,3] (also known as CDP-diacylglycerol synthase) (CDS) is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate (PA). CDP-diacylglycerol is an important branch point intermediate in both prokaryotic and eukaryotic organisms. CDS is a membrane-bound enzyme. As a signature pattern we selected a conserved region located in the C-terminal part.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

CDS, PS01315; Phosphatidate cytidylyltransferase signature  (PATTERN)


1AuthorsSparrow C.P., Raetz C.R.H.
TitlePurification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli.
SourceJ. Biol. Chem. 260:12084-12091(1985).
PubMed ID2995359

2AuthorsShen H., Heacock P.N., Clancey C.J., Dowhan W.
TitleThe CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth.
SourceJ. Biol. Chem. 271:789-795(1996).
PubMed ID8557688

3AuthorsSaito S., Goto K., Tonosaki A., Kondo H.
TitleGene cloning and characterization of CDP-diacylglycerol synthase from rat brain.
SourceJ. Biol. Chem. 272:9503-9509(1997).
PubMed ID9083091

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