We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC01019Phosphatidate cytidylyltransferase signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC01019
Description
Phosphatidate cytidylyltransferase (EC 2.7.7.41) [1,2,3] (also known as CDP-diacylglycerol synthase) (CDS) is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate (PA). CDP-diacylglycerol is an important branch point intermediate in both prokaryotic and eukaryotic organisms. CDS is a membrane-bound enzyme. As a signature pattern we selected a conserved region located in the C-terminal part.
Last update:December 2004 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Sparrow C.P. Raetz C.R.H. |
| Title | Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli. | |
| Source | J. Biol. Chem. 260:12084-12091(1985). | |
| PubMed ID | 2995359 |
| 2 | Authors | Shen H. Heacock P.N. Clancey C.J. Dowhan W. |
| Title | The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth. | |
| Source | J. Biol. Chem. 271:789-795(1996). | |
| PubMed ID | 8557688 |
| 3 | Authors | Saito S. Goto K. Tonosaki A. Kondo H. |
| Title | Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain. | |
| Source | J. Biol. Chem. 272:9503-9509(1997). | |
| PubMed ID | 9083091 |
Copyright
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