|PROSITE documentation PDOC50092|
The thrombospondin type-1 repeat (TSP1) was first identified as an about 55 amino acids long module present in thrombospondin 1 and 2 and in the circumsporozoite (CS) protein of Plasmodium . Since, a number of proteins involved in the complement pathway (properdin, C6, C7, C8A, C8B, C9) as well as extracellular matrix proteins like ADAMTS (see <PDOC50215>), mindin, F-spondin or SCO-spondin and TRAP proteins of Plasmodium have been found to contain one to seven TSP1s. Within these TSP1 modules, the WSXW and CSVTCG motifs are highly conserved although not ubiquitous. TSP1s may bind both protein and glycoconjugate ligands .
Averaged secondary structure predictions suggested that the TSP1 has an elongated structure and contains two amphipathic turn regions and one hydrophilic β-strand region . The six cysteines of the second TSP1 module of human thrombospondin 1 have been shown to be connected in a 1-5, 2-6, 3-4 disulfide-bond pattern. It is noteworthy that there are some members of the TSP1 module-family which lack certain pairs of cysteines that form disulfide-bonds .
Some proteins known to contain TSP1s are listed below:
The profile we developed covers the entire TSP1 domain.Last update:
October 2002 / Profile and text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Lawler J. Hynes R.O.|
|Title||The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.|
|Source||J. Cell Biol. 103:1635-1648(1986).|
|2||Authors||Adams J.C. Tucker R.P.|
|Title||The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development.|
|Source||Dev. Dyn. 218:280-299(2000).|
|3||Authors||Smith K.F. Nolan K.F. Reid K.B. Perkins S.J.|
|Title||Neutron and X-ray scattering studies on the human complement protein properdin provide an analysis of the thrombospondin repeat.|
|4||Authors||Roszmusz E. Patthy A. Trexler M. Patthy L.|
|Title||Structural characterization of the second TSP1-module of human thrombospondin.|
|Source||Biochem. Biophys. Res. Commun. 296:156-160(2002).|
|5||Authors||Iruela-Arispe M.L. Lombardo M. Krutzsch H.C. Lawler J. Roberts D.D.|
|6||Authors||Wengelnik K. Spaccapelo R. Naitza S. Robson K.J. Janse C.J. Bistoni F. Waters A.P. Crisanti A.|
|Title||The A-domain and the thrombospondin-related motif of Plasmodium falciparum TRAP are implicated in the invasion process of mosquito salivary glands.|
|Source||EMBO J. 18:5195-5204(1999).|