PROSITE documentation PDOC50128
SURP motif repeat profile


The SURP motif is an about 40-residue module, which has been named after the first proteins containing it (suppressor-of-white-apricot and PRP21/SPP91). It is found tandemly repeated in proteins involved in either constitutive or regulated pre-mRNA splicing. Overall, the N-terminal half of the SURP motif exhibits a higher conservation than the C-terminal half, where length differences are apparent in addition to sequence heterogeneity. Nevertheless, within this region, the motif F-x-F-L and the dipeptide Y-Y at the C-terminal border are conserved in nearly all proteins. The function of the SURP motif is still unknown [1,2,3,4].

Some proteins known to contain a SURP motif are listed below:

  • Drosophila suppressor-of-white-apricot (su(wa)) protein. It modulates a specific set of somatic, sex-independent pre-mRNA processing events.
  • Yeast PRP21/SPP91, a constitutive pre-mRNA splicing factor.
  • Vertebrate SWAP proteins, which are homologs of the su(wa) protein.
  • Mammalian SF3a120 splicing factor, the homolog of PRP21/SPP91.

The profile we developed covers the entire SURP motif.

Last update:

January 2003 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SURP, PS50128; SURP motif repeat profile  (MATRIX)


1AuthorsSpikes D.A. Kramer J. Bingham P.M. Van Doren K.
TitleSWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins.
SourceNucleic Acids Res. 22:4510-4519(1994).
PubMed ID7971282

2AuthorsDenhez F. Lafyatis R.
TitleConservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot.
SourceJ. Biol. Chem. 269:16170-16179(1994).
PubMed ID8206918

3AuthorsKraemer A. Mulhauser F. Wersig C. Groening K. Bilbe G.
SourceRNA 1:260-272(1995).

4AuthorsRain J.-C. Tartakoff A.M. Kraemer A. Legrain P.
TitleEssential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution.
SourceRNA 2:535-550(1996).
PubMed ID8718683

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