PROSITE documentation PDOC50128SURP motif repeat profile
The SURP motif is an about 40-residue module, which has been named after the first proteins containing it (suppressor-of-white-apricot and PRP21/SPP91). It is found tandemly repeated in proteins involved in either constitutive or regulated pre-mRNA splicing. Overall, the N-terminal half of the SURP motif exhibits a higher conservation than the C-terminal half, where length differences are apparent in addition to sequence heterogeneity. Nevertheless, within this region, the motif F-x-F-L and the dipeptide Y-Y at the C-terminal border are conserved in nearly all proteins. The function of the SURP motif is still unknown [1,2,3,4].
Some proteins known to contain a SURP motif are listed below:
- Drosophila suppressor-of-white-apricot (su(wa)) protein. It modulates a specific set of somatic, sex-independent pre-mRNA processing events.
- Yeast PRP21/SPP91, a constitutive pre-mRNA splicing factor.
- Vertebrate SWAP proteins, which are homologs of the su(wa) protein.
- Mammalian SF3a120 splicing factor, the homolog of PRP21/SPP91.
The profile we developed covers the entire SURP motif.
Last update:January 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Spikes D.A. Kramer J. Bingham P.M. Van Doren K. |
| Title | SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins. | |
| Source | Nucleic Acids Res. 22:4510-4519(1994). | |
| PubMed ID | 7971282 |
| 2 | Authors | Denhez F. Lafyatis R. |
| Title | Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot. | |
| Source | J. Biol. Chem. 269:16170-16179(1994). | |
| PubMed ID | 8206918 |
| 3 | Authors | Kraemer A. Mulhauser F. Wersig C. Groening K. Bilbe G. |
| Source | RNA 1:260-272(1995). |
| 4 | Authors | Rain J.-C. Tartakoff A.M. Kraemer A. Legrain P. |
| Title | Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution. | |
| Source | RNA 2:535-550(1996). | |
| PubMed ID | 8718683 |
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