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PROSITE documentation PDOC50135 |
The putative ZZ zinc finger, was first identified in the Dystrophin gene, a 427 kDa protein, involved in the Duchenne muscular dystrophy (DMD). This motif is also present in the adaptor proteins CBP and P300 in a region known to interact with YY1, E1A and TFIIB, which suggest a possible protein binding function for this domain [1]. It is closely related to the B-box zinc finger, (see <PDOC50119>) however B-box do not contain the Asp-Tyr-Asp-Leu motif present in most of the ZZ zinc fingers [2].
Some of the proteins containing this domain are listed below:
The ZZ zinc finger contains 7 positions able to coordinate one zinc atom, among them only 4 are completely conserved. Our pattern is based on these 4 positions. We have also developed a profile that spans the whole domain.
Last update:December 2004 / Pattern and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Giles R.H. Peters D.J. Breuning M.H. |
Title | Conjunction dysfunction: CBP/p300 in human disease. | |
Source | Trends Genet. 14:178-183(1998). | |
PubMed ID | 9613201 |
2 | Authors | Ponting C.P. Blake D.J. Davies K.E. Kendrick-Jones J. Winder S.J. |
Title | ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins. | |
Source | Trends Biochem. Sci. 21:11-13(1996). | |
PubMed ID | 8848831 |
3 | Authors | Potuschak T. Stary S. Schlogelhofer P. Becker F. Nejinskaia V. Bachmair A. |
Title | PRT1 of Arabidopsis thaliana encodes a component of the plant N-end rule pathway. | |
Source | Proc. Natl. Acad. Sci. U.S.A. 95:7904-7908(1998). | |
PubMed ID | 9653113 |