PROSITE documentation PDOC50827
DDT domain profile


The DDT has been named after the better characterized DNA-binding homeobox-containing proteins and the Different Transcription and chromatin remodeling factors in which it is found. It is a domain of about 60 amino acids which is exclusively associated with nuclear domains like AT-Hook (see <PDOC00306>), PHD finger (see <PDOC50016>), methyl-CpG-binding domain, bromodomain (see <PDOC00550>) and DNA-binding homeodomain (see <PDOC00027>).

The DDT domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three α helices. A DNA-binding function for the DDT domain has been proposed [1].

Proteins known to contain a DDT domain are listed below:

  • Bromodomain PHD finger transcription factors (BPTFs) from Caenorhabditis elegans, Drosophila and human. The human protein FALZ or FAC1 is believed to play arole in Alzheimer's disease.
  • Chromatin remodeling factors of the BAZ (bromodomain adjacent to zinc finger proteins)-family from Caenorhabditis elegans, Drosophila and human. The human BAZ protein WSTF is implicated in Wiliams Syndrome, a complex developmental disorder with multisystemic defects.
  • Homeodomain-containing proteins from Arabidopsis thaliana.
  • Hypothetical PHD-domain-containing protein from Arabidopsis thaliana.

The profile we developed covers the entire DDT domain.


The DDT domain was first identified in the BAZ family as part of a larger LH (Leucine-rich Helical) domain [2].

Last update:

September 2003 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

DDT, PS50827; DDT domain profile  (MATRIX)


1AuthorsDoerks T. Copley R. Bork P.
TitleDDT -- a novel domain in different transcription and chromosome remodeling factors.
SourceTrends Biochem. Sci. 26:145-146(2001).
PubMed ID11246006

2AuthorsJones M.H. Hamana N. Nezu J.I. Shimane M.
TitleA novel family of bromodomain genes.
SourceGenomics 63:40-45(2000).
PubMed ID10662543

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