PROSITE documentation PDOC50827DDT domain profile
The DDT has been named after the better characterized DNA-binding homeobox-containing proteins and the Different Transcription and chromatin remodeling factors in which it is found. It is a domain of about 60 amino acids which is exclusively associated with nuclear domains like AT-Hook (see <PDOC00306>), PHD finger (see <PDOC50016>), methyl-CpG-binding domain, bromodomain (see <PDOC00550>) and DNA-binding homeodomain (see <PDOC00027>).
The DDT domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three α helices. A DNA-binding function for the DDT domain has been proposed [1].
Proteins known to contain a DDT domain are listed below:
- Bromodomain PHD finger transcription factors (BPTFs) from Caenorhabditis elegans, Drosophila and human. The human protein FALZ or FAC1 is believed to play arole in Alzheimer's disease.
- Chromatin remodeling factors of the BAZ (bromodomain adjacent to zinc finger proteins)-family from Caenorhabditis elegans, Drosophila and human. The human BAZ protein WSTF is implicated in Wiliams Syndrome, a complex developmental disorder with multisystemic defects.
- Homeodomain-containing proteins from Arabidopsis thaliana.
- Hypothetical PHD-domain-containing protein from Arabidopsis thaliana.
The profile we developed covers the entire DDT domain.
Note:The DDT domain was first identified in the BAZ family as part of a larger LH (Leucine-rich Helical) domain [2].
Last update:September 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Doerks T. Copley R. Bork P. |
| Title | DDT -- a novel domain in different transcription and chromosome remodeling factors. | |
| Source | Trends Biochem. Sci. 26:145-146(2001). | |
| PubMed ID | 11246006 |
| 2 | Authors | Jones M.H. Hamana N. Nezu J.I. Shimane M. |
| Title | A novel family of bromodomain genes. | |
| Source | Genomics 63:40-45(2000). | |
| PubMed ID | 10662543 | |
| DOI | 10.1006/geno.1999.6071 |
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