PROSITE documentation PDOC50841DIX domain profile
Proteins of the dishevelled family (Dsh and Dvl) play a key role in the transduction of the Wg/Wnt signal (see <PDOC00219>) from the cell surface to the nucleus: in response to Wnt signal, they block the degradation of β-catenin by interacting with the scaffolding protein axin. The N-terminus of proteins of the dishevelled family and the C-terminus of proteins of the axin family share a region of homology of about 85 amino acids, which has been called DIX for DIshevelled and aXin [1]. The DIX domain is found associated with PDZ (see <PDOC50106>) and DEP (see <PDOC50186>) domains in proteins of the dishevelled family and with an RGS domain (see <PDOC50132>) in proteins of the axin family. DIX has been shown to be a protein-protein interaction domain that is important for homo- and hetero-oligomerization of proteins of the dishevelled and axin families [2,3,4,5]. The DIX domain has also be shown to be a signalling module that can target proteins to actin stress fibres and cytoplasmic vesicles to control Wnt signalling [6,7].
The Dvl2 DIX domain has been shown to form a predominantly helical structure [6].
The profile we developed covers the entire DIX domain.
Last update:December 2002 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Cadigan K.M. Nusse R. |
| Title | Wnt signaling: a common theme in animal development. | |
| Source | Genes Dev. 11:3286-3305(1997). | |
| PubMed ID | 9407023 |
| 2 | Authors | Kishida S. Yamamoto H. Hino S.-I. Ikeda S. Kishida M. Kikuchi A. |
| Title | DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. | |
| Source | Mol. Cell. Biol. 19:4414-4422(1999). | |
| PubMed ID | 10330181 |
| 3 | Authors | Sakanaka C. Williams L.T. |
| Title | Functional domains of axin. Importance of the C terminus as an oligomerization domain. | |
| Source | J. Biol. Chem. 274:14090-14093(1999). | |
| PubMed ID | 10318824 |
| 4 | Authors | Fukui A. Kishida S. Kikuchi A. Asashima M. |
| Title | Effects of rat Axin domains on axis formation in Xenopus embryos. | |
| Source | Dev. Growth Differ. 42:489-498(2000). | |
| PubMed ID | 11041490 |
| 5 | Authors | Julius M.A. Schelbert B. Hsu W. Fitzpatrick E. Jho E. Fagotto F. Costantini F. Kitajewski J. |
| Title | Domains of axin and disheveled required for interaction and function in wnt signaling. | |
| Source | Biochem. Biophys. Res. Commun. 276:1162-1169(2000). | |
| PubMed ID | 11027605 | |
| DOI | 10.1006/bbrc.2000.3607 |
| 6 | Authors | Capelluto D.G.S. Kutateladze T.G. Habas R. Finkielstein C.V. He X. Overduin M. |
| Title | The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. | |
| Source | Nature 419:726-729(2002). | |
| PubMed ID | 12384700 | |
| DOI | 10.1038/nature01056 |
| 7 | Authors | Smallridge R. |
| Source | Nat. Rev. Mol. Cell Biol. 3:807-807(2002). |
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