PROSITE documentation PDOC50841
DIX domain profile


Proteins of the dishevelled family (Dsh and Dvl) play a key role in the transduction of the Wg/Wnt signal (see <PDOC00219>) from the cell surface to the nucleus: in response to Wnt signal, they block the degradation of β-catenin by interacting with the scaffolding protein axin. The N-terminus of proteins of the dishevelled family and the C-terminus of proteins of the axin family share a region of homology of about 85 amino acids, which has been called DIX for DIshevelled and aXin [1]. The DIX domain is found associated with PDZ (see <PDOC50106>) and DEP (see <PDOC50186>) domains in proteins of the dishevelled family and with an RGS domain (see <PDOC50132>) in proteins of the axin family. DIX has been shown to be a protein-protein interaction domain that is important for homo- and hetero-oligomerization of proteins of the dishevelled and axin families [2,3,4,5]. The DIX domain has also be shown to be a signalling module that can target proteins to actin stress fibres and cytoplasmic vesicles to control Wnt signalling [6,7].

The Dvl2 DIX domain has been shown to form a predominantly helical structure [6].

The profile we developed covers the entire DIX domain.

Last update:

December 2002 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

DIX, PS50841; DIX domain profile  (MATRIX)


1AuthorsCadigan K.M. Nusse R.
TitleWnt signaling: a common theme in animal development.
SourceGenes Dev. 11:3286-3305(1997).
PubMed ID9407023

2AuthorsKishida S. Yamamoto H. Hino S.-I. Ikeda S. Kishida M. Kikuchi A.
TitleDIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
SourceMol. Cell. Biol. 19:4414-4422(1999).
PubMed ID10330181

3AuthorsSakanaka C. Williams L.T.
TitleFunctional domains of axin. Importance of the C terminus as an oligomerization domain.
SourceJ. Biol. Chem. 274:14090-14093(1999).
PubMed ID10318824

4AuthorsFukui A. Kishida S. Kikuchi A. Asashima M.
TitleEffects of rat Axin domains on axis formation in Xenopus embryos.
SourceDev. Growth Differ. 42:489-498(2000).
PubMed ID11041490

5AuthorsJulius M.A. Schelbert B. Hsu W. Fitzpatrick E. Jho E. Fagotto F. Costantini F. Kitajewski J.
TitleDomains of axin and disheveled required for interaction and function in wnt signaling.
SourceBiochem. Biophys. Res. Commun. 276:1162-1169(2000).
PubMed ID11027605

6AuthorsCapelluto D.G.S. Kutateladze T.G. Habas R. Finkielstein C.V. He X. Overduin M.
TitleThe DIX domain targets dishevelled to actin stress fibres and vesicular membranes.
SourceNature 419:726-729(2002).
PubMed ID12384700

7AuthorsSmallridge R.
SourceNat. Rev. Mol. Cell Biol. 3:807-807(2002).

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