PROSITE documentation PDOC50859
Longin domain profile


The longin domain is an about 110-residue domain found at the N-terminus of numerous proteins, that structurally and (possibly) functionally defines a novel family of vesicle-associated memmbrane proteins (VAMPs) called long VAMPs or longins. The longin domain is associated to a C-terminal domain, which is strongly homologous to the synaptobrevin domain of brevins. Longins are common to yeast, protists, animals and plants. Wide distribution of the longin domain throughout eukaryotes suggests a generic but very important function. It has been proposed that the longin domain might be involved in the regulation of membrane fusion [1].

The profile we developed covers the entire longin domain.

Expert(s) to contact by email:

Filippini F.

Last update:

July 2003 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

LONGIN, PS50859; Longin domain profile  (MATRIX)


1AuthorsFilippini F. Rossi V. Galli T. Budillon A. D'Urso M. D'Esposito M.
TitleLongins: a new evolutionary conserved VAMP family sharing a novel SNARE domain.
SourceTrends Biochem. Sci. 26:407-409(2001).
PubMed ID11440841

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