PROSITE documentation PDOC50859Longin domain profile
The longin domain is an about 110-residue domain found at the N-terminus of numerous proteins, that structurally and (possibly) functionally defines a novel family of vesicle-associated memmbrane proteins (VAMPs) called long VAMPs or longins. The longin domain is associated to a C-terminal domain, which is strongly homologous to the synaptobrevin domain of brevins. Longins are common to yeast, protists, animals and plants. Wide distribution of the longin domain throughout eukaryotes suggests a generic but very important function. It has been proposed that the longin domain might be involved in the regulation of membrane fusion [1].
The profile we developed covers the entire longin domain.
Expert(s) to contact by email: Last update:July 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Filippini F. Rossi V. Galli T. Budillon A. D'Urso M. D'Esposito M. |
| Title | Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain. | |
| Source | Trends Biochem. Sci. 26:407-409(2001). | |
| PubMed ID | 11440841 |
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