|PROSITE documentation PDOC50884|
The Dof (DNA-binding with one finger) Cys2/Cys2-type zing finger is an around 50 amino acid motif found in plant transcription factors involved in the regulation of various processes. The arrangement of cysteines has some significant ressemblance to GATA (see <PDOC00300>) and steroid hormone receptor (see <PDOC00031>) zinc fingers . Like other zinc fingers the Dof domain has a dual activity: it binds DNA in a sequence-specific manner with the core binding site formed by the AAAG sequence  and it can also mediates protein-protein interaction (see below).
Some of the proteins known to contain a Dof zinc finger are listed below:
The pattern we developed covers the whole zinc finger and the first eight amino acids of the conserved basic C-terminal tail essential for the DNA binding activity . We also developed a profile that spans the whole domain.Last update:
December 2004 / Pattern and text revised.
PROSITE methods (with tools and information) covered by this documentation:
|Title||The Dof family of plant transcription factors.|
|Source||Trends Plant Sci. 7:555-560(2002).|
|2||Authors||Zhang B. Chen W. Foley R.C. Buttner M. Singh K.B.|
|Title||Interactions between distinct types of DNA binding proteins enhance binding to ocs element promoter sequences.|
|Source||Plant Cell 7:2241-2252(1995).|
|3||Authors||Shimofurutani N. Kisu Y. Suzuki M. Esaka M.|
|Title||Functional analyses of the Dof domain, a zinc finger DNA-binding domain, in a pumpkin DNA-binding protein AOBP.|
|Source||FEBS Lett. 430:251-256(1998).|