PROSITE documentation PDOC50904
PRELI/MSF1 domain profile


The PRELI/MSF1 domain is an eukaryotic protein module which occurs in stand-alone form in several proteins, including the human PRELI protein and the yeast MSF1 protein, and as an amino-terminal domain in an orthologous group of proteins typified by human SEC14L1, which is conserved in all animals. In this group of proteins, the PRELI/MSF1 domain co-occurs with the CRAL-TRIO (see <PDOC50191>) and the GOLD domains (see <PDOC50866>). The PRELI/MSF1 domain is approximately 170 residues long and is predicted to assume a globular α + β fold with six β strands and four α helices. It has been suggested that the PRELI/MSF1 domain may have a function associated with cellular membrane [1].

The profile we developed covers the entire PRELI/MSF1 domain.

Last update:

April 2003 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PRELI_MSF1, PS50904; PRELI/MSF1 domain profile  (MATRIX)


1AuthorsAnantharaman V. Aravind L.
TitleThe GOLD domain, a novel protein module involved in Golgi function and secretion.
SourceGenome Biol. 3:1-7(2002).
PubMed ID12049664

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