PROSITE documentation PDOC50904PRELI/MSF1 domain profile
The PRELI/MSF1 domain is an eukaryotic protein module which occurs in stand-alone form in several proteins, including the human PRELI protein and the yeast MSF1 protein, and as an amino-terminal domain in an orthologous group of proteins typified by human SEC14L1, which is conserved in all animals. In this group of proteins, the PRELI/MSF1 domain co-occurs with the CRAL-TRIO (see <PDOC50191>) and the GOLD domains (see <PDOC50866>). The PRELI/MSF1 domain is approximately 170 residues long and is predicted to assume a globular α + β fold with six β strands and four α helices. It has been suggested that the PRELI/MSF1 domain may have a function associated with cellular membrane [1].
The profile we developed covers the entire PRELI/MSF1 domain.
Last update:April 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Anantharaman V. Aravind L. |
| Title | The GOLD domain, a novel protein module involved in Golgi function and secretion. | |
| Source | Genome Biol. 3:1-7(2002). | |
| PubMed ID | 12049664 |
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