PROSITE documentation PDOC50969
FCP1 homology domain profile


Yeast FCP1 is an essential protein serine phosphatase (EC that dephosphorylates the C-terminal domain (CTD) of RNA polymerase II. FCP1 orthologs are present in all known eukaryote proteomes. The N-terminal domain of FCP1 corresponds to the catalytic unit of the phosphatase and has been refered to as the FCP1 homology domain. The FCP1 homology domain, which is a ~180-residue module, is also found in many other proteins of unknown function. It contains a DxDx(T/V) motif preceded by four hydrophobic residues characteristic of a large family of metal-dependent phosphohydrolases and phosphotransferases. The first aspartate residue is likely to participate in catalysis, whereas the second could have a role in substrate recognition [1,2,3,4].

The profile we developed covers the entire FCP1 homology domain.

Last update:

March 2004 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

FCP1, PS50969; FCP1 homology domain profile  (MATRIX)


1AuthorsArchambault J. Chambers R.S. Kobor M.S. Ho Y. Cartier M. Bolotin D. Andrews B. Kane C.M. Greenblatt J.
TitleAn essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae.
SourceProc. Natl. Acad. Sci. U.S.A. 94:14300-14305(1997).
PubMed ID9405607

2AuthorsKobor M.S. Archambault J. Lester W. Holstege F.C.P. Gileadi O. Jansma D.B. Jennings E.G. Kouyoumdjian F. Davidson A.R. Young R.A. Greenblatt J.
TitleAn unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.
SourceMol. Cell 4:55-62(1999).
PubMed ID10445027

3AuthorsHausmann S. Shuman S.
TitleDefining the active site of Schizosaccharomyces pombe C-terminal domain phosphatase Fcp1.
SourceJ. Biol. Chem. 278:13627-13632(2003).
PubMed ID12556522

4AuthorsCho H. Kim T.-K. Mancebo H. Lane W.S. Flores O. Reinberg D.
TitleA protein phosphatase functions to recycle RNA polymerase II.
SourceGenes Dev. 13:1540-1552(1999).
PubMed ID10385623

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