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PROSITE documentation PDOC51029 |
The myb/SANT-like domain in Adf-1 (MADF) is a ~80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple trinucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain (see <PDOC51031>) [1,2,3].
It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains [1,2,3].
Some proteins known to contain a MADF domain are listed below:
The profile we developed covers the entire MADF domain.
Last update:October 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | England B.P. Admon A. Tjian R. |
Title | Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb oncoproteins. | |
Source | Proc. Natl. Acad. Sci. U.S.A. 89:683-687(1992). | |
PubMed ID | 1731341 |
2 | Authors | Cutler G. Perry K.M. Tjian R. |
Title | Adf-1 is a nonmodular transcription factor that contains a TAF-binding Myb-like motif. | |
Source | Mol. Cell. Biol. 18:2252-2261(1998). | |
PubMed ID | 9528796 |
3 | Authors | Bhaskar V. Courey A.J. |
Title | The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist. | |
Source | Gene 299:173-184(2002). | |
PubMed ID | 12459265 |