PROSITE documentation PDOC51029MADF domain profile
The myb/SANT-like domain in Adf-1 (MADF) is a ~80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple trinucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain (see <PDOC51031>) [1,2,3].
It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains [1,2,3].
Some proteins known to contain a MADF domain are listed below:
- Drosophila Adf-1, a transcription factor first identified on the basis of its interaction with the alcohol dehydrogenase promoter but that binds the promoters of a diverse group of genes [1].
- Drosophila Dorsal-interacting protein 3 (Dip3). It functions both as an activator to bind DNA in a sequence specific manner and a coactivator to stimulate synergistic activation by Dorsal and Twist [2].
- Drosophila Stonewall (Stwl), a putative transcription factor required for maintenance of female germline stem cells as well as oocyte differentiation.
The profile we developed covers the entire MADF domain.
Last update:October 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | England B.P. Admon A. Tjian R. |
| Title | Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb oncoproteins. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:683-687(1992). | |
| PubMed ID | 1731341 |
| 2 | Authors | Cutler G. Perry K.M. Tjian R. |
| Title | Adf-1 is a nonmodular transcription factor that contains a TAF-binding Myb-like motif. | |
| Source | Mol. Cell. Biol. 18:2252-2261(1998). | |
| PubMed ID | 9528796 |
| 3 | Authors | Bhaskar V. Courey A.J. |
| Title | The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist. | |
| Source | Gene 299:173-184(2002). | |
| PubMed ID | 12459265 |
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