Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51031BESS domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51031
The BESS domain is a ~40 amino acid module that has been named after the three proteins that originally defined the domain: Boundary element associated factor 32, Su(var)3-7, and Stonewall. The BESS domain directs a variety of protein-protein interactions, including interactions with itself, with Dorsal, and with a TBP-associated factor. It is found in a single copy in drosophila proteins and is often associated with the MADF domain (see <PDOC51029>) [1,2,3].
It has been suggested that the BESS domain might be related to the myb/SANT HTH domain. Consistent with the possibility of a relationship to the myb/SANT domain, the BESS domain secondary structure prediction suggests the existence of three α-helices [1,2,3].
Some proteins known to contain a BESS domain are listed below:
- Drosophila Boundary element associated factor 32 (BEAF-32).
- Drosophila Suppressor of variegation protein 3-7 (Su(var)3-7). It could play a role in chromosome condensation.
- Drosophila Ravus. It is homologous to the C-terminal part of Su(var)3-7 [4].
- Drosophila Stonewall (Stwl), a putative transcription factor required for maintenance of female germline stem cells as well as oocyte differentiation.
- Drosophila Adf-1, a transcription factor first identified on the basis of its interaction with the alcohol dehydrogenase promoter but that binds the promoters of a diverse group of genes [1].
- Drosophila Dorsal-interacting protein 3 (Dip3). It functions both as an activator to bind DNA in a sequence specific manner and a coactivator to stimulate synergistic activation by Dorsal and Twist [2].
The profile we developed covers the entire BESS domain.
Last update:October 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | England B.P. Admon A. Tjian R. |
| Title | Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb oncoproteins. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:683-687(1992). | |
| PubMed ID | 1731341 |
| 2 | Authors | Cutler G. Perry K.M. Tjian R. |
| Title | Adf-1 is a nonmodular transcription factor that contains a TAF-binding Myb-like motif. | |
| Source | Mol. Cell. Biol. 18:2252-2261(1998). | |
| PubMed ID | 9528796 |
| 3 | Authors | Bhaskar V. Courey A.J. |
| Title | The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist. | |
| Source | Gene 299:173-184(2002). | |
| PubMed ID | 12459265 |
| 4 | Authors | Delattre M. Spierer A. Hulo N. Spierer P. |
| Title | A new gene in Drosophila melanogaster, Ravus, the phantom of the modifier of position-effect variegation Su(var)3-7. | |
| Source | Int. J. Dev. Biol. 46:167-171(2002). | |
| PubMed ID | 11902679 |
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