PROSITE documentation PDOC51036
Zinc finger A20-type profile


NF-kappaB transcription factors mediate the effects of pro-inflammatory cytokines such as TNF-α and interleukin-1 β. Failure to downregulate NF-kappaB transcriptional activity results in chronic inflammation and cell death [1]. It has been shown that A20 protein can downregulates NF-kappaB signaling by targeting receptor interacting protein (RIP), an essential mediator of the proximal TNF receptor 1 (TNFR1) signalling complex, to the proteasome [2].

The C-terminal region of A20, is composed of seven C4-type zinc fingers, that function as a ubiquitin ligase by polyubiquitinating RIP with Lys-48-linked ubiquitin chains, thereby targeting RIP for proteasomal degradation [2].

A20-type zinc fingers are found in all eukaryotes and form fusions with a variety of domains involved in ubiquitin signaling pathways.

The profile we developed covers the whole A20-type zinc finger.

Last update:

November 2004 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_A20, PS51036; Zinc finger A20-type profile  (MATRIX)


1AuthorsDixit V. Mak T.W.
TitleNF-kappaB signaling. Many roads lead to madrid.
SourceCell 111:615-619(2002).
PubMed ID12464174

2AuthorsWertz I.E. O'Rourke K.M. Zhou H. Eby M. Aravind L. Seshagiri S. Wu P. Wiesmann C. Baker R. Boone D.L. Ma A. Koonin E.V. Dixit V.M.
TitleDe-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
SourceNature 430:694-699(2004).
PubMed ID15258597

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