The KASH (for Klarsicht/ANC-1/Syne-1 homology) or KLS domain is a highly
hydrophobic nuclear envelope localization domain of ~60 amino acids comprising
an ~20-amino-acid transmembrane region and a 30-35-residue C-terminal region
that lies between the inner and the outer nuclear membranes. The KASH domain
is found in association with other domains, such as spectrin repeats and CH
(see <PDOC50021>), at the C-terminus of proteins tethered to the nuclear
membrane in diverse cell types [1,2,3,4,5].
Some proteins known to contain a KASH domain are listed below:
Caenorhabditis elegans nuclear anchorage protein 1 (ANC-1).
Drosophila Klarsicht (Klar), a protein associated with nuclei and required
for a subset of nuclear migrations.
Vetebrate nesprin-1 and -2 (also known as Syne-1 and -2). They are
associated with emerin and lamin A at the nuclear envelope of muscle cells
and other cell types.
The profile we developed covers the entire KASH domain.
December 2004 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Mosley-Bishop K.L. Li Q. Patterson L. Fischer J.A.
Curr. Biol. 9:1211-1220(1999).
Apel E.D. Lewis R.M. Grady R.M. Sanes J.R.
Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.
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