PROSITE documentation PDOC51050
Zinc finger CW-type profile


The CW domain is composed of four conserved cysteines and two tryptophan residues. The four cysteines could coordinate one zinc atom to form a new type of zinc finger. It is found exclusively in vertebrate, vertebrate-infected parasites and higher plants. The function of this zinc finger is not yet known but its taxonomic distribution and its association with a variety of domains involved in DNA binding, methylation, chromatin structure or ubiquitination suggest a putative role in epigenetic mechanisms and embryonic development [1].

The profile we developed covers the whole CW-type zinc finger.

Last update:

December 2004 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_CW, PS51050; Zinc finger CW-type profile  (MATRIX)


1AuthorsPerry J. Zhao Y.
TitleThe CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants.
SourceTrends Biochem. Sci. 28:576-580(2003).
PubMed ID14607086

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