PROSITE documentation PDOC51050Zinc finger CW-type profile
The CW domain is composed of four conserved cysteines and two tryptophan residues. The four cysteines could coordinate one zinc atom to form a new type of zinc finger. It is found exclusively in vertebrate, vertebrate-infected parasites and higher plants. The function of this zinc finger is not yet known but its taxonomic distribution and its association with a variety of domains involved in DNA binding, methylation, chromatin structure or ubiquitination suggest a putative role in epigenetic mechanisms and embryonic development [1].
The profile we developed covers the whole CW-type zinc finger.
Last update:December 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Perry J. Zhao Y. |
| Title | The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. | |
| Source | Trends Biochem. Sci. 28:576-580(2003). | |
| PubMed ID | 14607086 |
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