PROSITE documentation PDOC51083Zinc finger HIT-type profile
The HIT-type zinc finger contains 7 conserved cysteines and one histidine that can potentially coordinate two zinc atoms. It has been named after the first protein that originally defined the domain: the yeast HIT1 protein [1]. The HIT-type zinc finger displays some sequence similarities to the MYND-type zinc finger (see <PDOC50865>). The function of this domain is unknown but it is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling.
Some proteins known to contain a HIT-type zinc finger are listed below:
- Mammalian thyroid hormone receptors interacting protein 3 (Trip3). It also interacts with the retinoid X receptor and activates the transcriptional factor HNF-4α [2].
- Mammalian FON protein.
- Yeast HIT1 protein. It is required for high temperature growth.
- Yeast VPS71 protein. It is a component of the chromatin remodeling complex Swr1, which catalyzes the exchange of histone H2A to histone variant H2AZ. This step has an important influence on gene expression [3].
The profile we developed covers the whole HIT-type zinc finger.
Last update:February 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Kawakami K. Shafer B.K. Garfinkel D.J. Strathern J.N. Nakamura Y. |
| Title | Ty element-induced temperature-sensitive mutations of Saccharomyces cerevisiae. | |
| Source | Genetics 131:821-832(1992). | |
| PubMed ID | 1325386 |
| 2 | Authors | Iwahashi H. Yamagata K. Yoshiuchi I. Terasaki J. Yang Q. Fukui K. Ihara A. Zhu Q. Asakura T. Cao Y. Imagawa A. Namba M. Hanafusa T. Miyagawa J. Matsuzawa Y. |
| Title | Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha. | |
| Source | Diabetes 51:910-914(2002). | |
| PubMed ID | 11916906 |
| 3 | Authors | Mizuguchi G. Shen X. Landry J. Wu W.H. Sen S. Wu C. |
| Title | ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. | |
| Source | Science 303:343-348(2004). | |
| PubMed ID | 14645854 | |
| DOI | 10.1126/science.1090701 |
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