PROSITE documentation PDOC51301KilA-N domain profile
The amino-terminal module of the poxvirus D6R/NIR proteins defines a novel conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses [1]. Putative proteins with homology to the KilA-N domain have also been identified in Maverick transposable elements of the parabasalid protozoa Trichomonas vaginalis [2]. The KilA-N domain has been suggested to be homologous to the fungal DNA-binding APSES domain (see <PDOC51299>). In all proteins shown to contain the KilA-N domain, it occurs at the extreme amino terminus accompanied by a wide range of distinct carboxy-terminal domains. These carboxy-terminal modules may be enzymes, such as the nuclease domains, or might mediate additional, specific interactions with nucleic acids or proteins, like the RING (see <PDOC00449>) or CCCH fingers in the poxviruses [1].
The KilA-N domain is predicted to adopt an α+β fold with four conserved strands and at least two conserved helices [1].
Some proteins known to contain a KilA-N domain are listed below:
- Bacteriophage P1 protein kilA.
- Fowlpox virus (FPV) protein FPV236.
- Fowlpox virus (FPV) hypothetical protein FPV248.
- Vaccinia virus hypothetical 21.7 kDa HindIII-C protein.
The profile we developed covers the entire KilA-N domain.
Last update:March 2007 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Iyer L.M. Koonin E.V. Aravind L. |
| Title | Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors. | |
| Source | Genome Biol. 3:RESEARCH0012-RESEARCH0012(2002). | |
| PubMed ID | 11897024 |
| 2 | Authors | Pritham E.J. Putliwala T. Feschotte C. |
| Title | Mavericks, a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses. | |
| Source | Gene 390:3-17(2007). | |
| PubMed ID | 17034960 | |
| DOI | 10.1016/j.gene.2006.08.008 |
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